Etidronate (Disodium)

Etidronate is used to treat Paget's disease of the bone. It may also be used to treat or prevent a certain type of bone problem (heterotopic ossification) after hip replacement surgery or spinal injury. Etidronate is also used to treat hypercalcemia (too much calcium in the blood) that may occur with some types of cancer. This medicine is available only with your doctor's prescription.

Etidronate is used to treat Paget's disease of the bone. It may also be used to treat or prevent a certain type of bone problem (heterotopic ossification) after hip replacement surgery or spinal injury. Etidronate is also used to treat hypercalcemia (too much calcium in the blood) that may occur with some types of cancer. This medicine is available only with your doctor's prescription.

Etidronate (Disodium) is contraindicated in conditions like Osteolytic Paget's disease, Pregnancy, Breastfeeding, Pain and inflammation (rheumatic disease),Vasomotor symptoms in estrogen deficiency.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bone pain or tenderness (increased, continuing, or returning—in patients with Paget's disease) Less common Bone fractures, especially of the thigh bone Rare Abdominal or stomach pain or burning bloody, black, or tarry stools chest pain chills cough or hoarseness fever general feeling of tiredness or weakness hives lower back or side pain noisy breathing painful or difficult urination pale skin skin rash or itching sore throat sores, ulcers, or white spots on the lips or inside the mouth swelling of the arms, legs, face, lips, tongue, or throat swollen glands tightness in the chest unusual bleeding or bruising Incidence not known Blistering, peeling, loosening of the skin bone, joint, or muscle pain that is severe and occasionally disabling burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings difficulty in moving difficulty in swallowing discouragement feeling sad or empty heartburn heavy jaw feeling irritability lack of appetite large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs loosening of a tooth loss of interest or pleasure loss of memory pain or burning in the throat pain, swelling, or numbness in the mouth or jaw problems with memory rash with flat lesions or small raised lesions on the skin red irritated eyes red skin lesions, often with a purple center redness or discoloration of the skin seeing, hearing, or feeling things that are not there trouble concentrating trouble sleeping unusual tiredness or weakness vomiting Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Abdominal or stomach cramps confusion convulsions difficulty in breathing irregular heartbeats mood or mental changes muscle cramps in the hands, arms, feet, legs, or face numbness and tingling around the mouth, fingertips, or feet shortness of breath tremor Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea nausea Incidence not known Burning feeling in the chest or stomach hair loss, thinning of hair headache indigestion leg cramps stomach upset tenderness in the stomach area Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Patients who are on calcium and vitamin D restriction may be more sensitive to the effects of etidronate. Patients should be sure to maintain appropriate dietary intake of vitamin D and calcium while receiving this medication. Etidronate can cause diarrhea, particularly when high doses are administered, and the drug should be used with caution, if at all, in patients with enterocolitis. It should be used with caution in patients with renal impairment or a decreased glomerular filtration rate. It should be used during pregnancy only if the potential benefits to the mother outweighs the potential risks to the fetus.

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

5 to 20 mg/kg (12 (12.5)) 24 hourly PO — For max 6 Months

Safety not established ( ) —

( ) — Not recommended in this age group

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Store Between 20°C-25°C. Tab Store Below 40°C. Protect from Sunlight and Moisture.