Factor VIII
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Factor VIII is a blood clotting factor. Factor VIII is used to stop episodes of uncontrollable bleeding in hemophilia and von Willebrand disease.
Indications
Factor VIII is primarily indicated in conditions like Hemophilia A congenital, Hemorrhage, Von Willebrand disease, and can also be given in adjunctive therapy as an alternative drug of choice in Willebrand's disease.
Contraindications
Factor VIII is contraindicated in conditions like Hypersensitivity to any component of product.
Side Effects
The severe or irreversible adverse effects of Factor VIII, which give rise to further complications include Hepatitis, Paresthesia, Factor VIII produces potentially life-threatening effects which include Anaphylaxis, Fulminant hepatitis, AIDS, which are responsible for the discontinuation of Factor VIII therapy. The signs and symptoms that are produced after the acute over dosage of Factor VIII include Paradoxical hemorrhage, Coombs positive hemolytic anemia. The symptomatic adverse reactions produced by Factor VIII are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Palpitation, Urticaria, Fulness in head, Warm flush, GI disturbance, Chills fever, Dyspnea, Pyrexia, Dyspnea, Hypotension, Arthralgia, Taste disorder, Pruritus, Rash.
Warnings
It should be used only if clearly needed during pregnancy. It should be used with caution in patients with any pre-existing diseases or any allergies. Before and during injection check heart rate. The dose or rate of infusion may need to be changed if heart rate is too fast. Monitor for development of factor VIII inhibitors, Intravascular haemolysis after large or frequently repeated doses in patients with blood groups A, B or AB
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
8 to 60 IU/kg (34 (34)) As recommended. Slow IV — As Required
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Factor VIII was found.
Storage
Inj Do not Freeze.
Available Brands in Pakistan
1 active brand listed alphabetically.
ACTIF-VIII
ActiveSIND MEDICAL STORES
DML: ACTIF-VIII
Inj
1 additional record is present but flagged "Unverified / Legacy" and not listed.