Febuxostat
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Febuxostat reduces the production of uric acid in your body. A build-up of uric acid can cause gout symptoms.
Febuxostat is used to keep uric acid levels from getting to high in people with gout.
Febuxostat is for use only in people who cannot take another medicine called allopurinol , or when allopurinol has stopped working.
Febuxostat may also be used for purposes not listed in this medication guide.
Indications
Febuxostat reduces the production of uric acid in your body. A build-up of uric acid can cause gout symptoms.
Febuxostat is used to keep uric acid levels from getting to high in people with gout.
Febuxostat is for use only in people who cannot take another medicine called allopurinol , or when allopurinol has stopped working.
Febuxostat may also be used for purposes not listed in this medication guide.
Contraindications
You should not use febuxostat if you are allergic to it, or if you also use:
azathioprine; or mercaptopurine.
Taking febuxostat may increase your risk of serious or fatal heart problems. Talk with your doctor about the risks and benefits of febuxostat.
Tell your doctor if you have ever had:
heart problems; a heart attack or stroke ; liver or kidney disease; cancer ; Lesch-Nyhan syndrome ; or an organ transplant (kidney, liver, lung, heart).
Tell your doctor if you are pregnant or breastfeeding.
Side Effects
Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat , burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Febuxostat may cause serious side effects. Call your doctor at once if you have:
a light-headed feeling, like you might pass out; heart attack symptoms --chest pain or pressure, pain spreading to your jaw or shoulder, fast heartbeats, shortness of breath ; liver problems --stomach pain (upper right side), unusual tiredness, dark urine, jaundice (yellowing of the skin or eyes); or signs of a stroke --sudden numbness or weakness (especially on one side of the body), sudden severe headache , slurred speech, problems with vision or balance.
Common side effects of febuxostat may include:
gout flares , joint pain ; nausea; mild rash; or liver problems.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Taking febuxostat may increase your risk of serious or fatal heart problems. Seek medical attention if you have chest pain, trouble breathing, fast heartbeats, sudden severe headache, numbness or weakness on one side of your body, or problems with vision or speech.
You should not use febuxostat if you also use azathioprine or mercaptopurine .
High Risk Groups
Taking febuxostat may increase your risk of serious or fatal heart problems. Seek medical attention if you have chest pain, trouble breathing, fast heartbeats, sudden severe headache, numbness or weakness on one side of your body, or problems with vision or speech.
You should not use febuxostat if you also use azathioprine or mercaptopurine .
Adult Dosage
40 to 40 mg (40 (40)) 24 hourly PO — This is the starting dose for hyperuricemia patients with gout. It can be taken with or without food.
80 to 80 mg (80 (80)) 24 hourly PO — This is the dose for patients who do not achieve a serum uric acid less then 6mg/dl after 2 weeks with 40mg dose. It can be taken with or without food.
Scraped Dose — Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may take febuxostat with or without food. Febuxostat may be taken with an antacid if needed.
You may have an increase in gout symptoms (flares) when you first start taking febuxostat. Your doctor may prescribe other medications for you to use during the first 6 months of treatment with febuxostat.
You should not stop using febuxostat suddenly. Stopping suddenly may make your condition worse.
For best results, keep using your medications as directed. Call your doctor if your symptoms do not improve after 6 months, or if they get worse.
You will need frequent blood tests to check your liver function.
Store at room temperature away from moisture, heat, and light.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Tell your doctor about all your other medicines, especially:
theophylline .
This list is not complete. Other drugs may affect febuxostat, including prescription and over-the-counter medicines, vitamins , and herbal products . Not all possible drug interactions are listed here.
Storage
Tablet Store Between 15°C-30°C. Protect from Sunlight.
Available Brands in Pakistan
6 active brands listed alphabetically.
ADENURIC
ActiveS.J. & G. FAZUL ELLAHIE (PVT) LTD.
DML: ADENURIC
Tabs
FEBORIC
ActiveEFROZE CHEMICAL INDUSTRIES (PVT) LTD.
DML: FEBORIC
Tabs
FEBULOUS
ActiveGENOME PHARMACEUTICALS (PVT) LTD
DML: FEBULOUS
Tabs
GOURIC
ActivePHARMEVO (PVT) LTD.
DML: GOURIC
Tabs
ULORA
ActiveHELIX PHARMA (PRIVATE) LIMITED
DML: ULORA
Tabs
ZURIG
ActiveGETZ PHARMA PAKISTAN (PVT) LTD.
DML: ZURIG
Tabs
3 additional records are present but flagged "Unverified / Legacy" and not listed.
