Fosfestrol
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Fosfestrol is a synthetic non-steroidal estrogen (hormone). Fosfestrol is also known as diethylstilbestrol diphosphate (DESDP), is an estrogen medication which is used in the treatment of prostate cancer in men.
Indications
Fosfestrol is primarily indicated in conditions like Adjunct in the treatment of opioid dependence, Breast cancer, Dermatomyositis, Nasopharyngeal fibromas, Oncology, Parathyroid carcinoma, Plasmacytomas, Prostatic cancer, Rheumatoid arthritis.
Contraindications
Fosfestrol is contraindicated in conditions like Hypertension,Cardiac failure,Liver diseases,Cerebrovascular disease.
Side Effects
The severe or irreversible adverse effects of Fosfestrol, which give rise to further complications include Congestive heart failure, Breast tenderness, Pulmonary embolism, Pulmonary thrombosis, CVA, Bone marrow toxicity, Mental disturbances, Breast enlargement, Testicular atrophy. Fosfestrol produces potentially life-threatening effects which include Thromboembolic cardiovascular accidents, Fluid & sodium retention, which are responsible for the discontinuation of Fosfestrol therapy. The signs and symptoms that are produced after the acute overdosage of Fosfestrol include Fluid retention. The symptomatic adverse reactions produced by Fosfestrol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Anorexia, Diarrhea, Fever, Nausea and vomiting, Perineal pruritus, Perineal pain.
Warnings
High doses of estrogen used in treatment of malignant disease should be used cautiously in patients with cerebrovascular disorder, cardiovascular disease, coronary artery disease, venous thromboembolism or liver impairment. Estrogens should be used with caution in children, because premature closure of epiphysis may occur resulting in inhibited linear growth and small stature. Slow infusion is not recommended, because cytotoxic concentration of drug is not achieved. It is not recommended for use during pregnancy.
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
3.571 mg/kg (3.6 (3.571)) 8 hourly IV — Maintenance, per week
7.142 to 14.285 mg/kg (11 (10.7135)) 24 hourly IV — Initially for 5 Days or As Required
Child Dosage
Unlikely to be used in this age group ( ) —
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Fosfestrol was found.
Storage
Tab, Inj Store Below 25°C.
Available Brands in Pakistan
No brands are recorded for this generic.