Gallium Nitrate

Gallium Nitrate is an inorganic metallic salt that inhibits bone resorption and is used for its hypocalcemic properties. Gallium Nitrate is used in the treatment of hypercalcemia associated with malignant neoplasm and in other disorders associated with abnormally enhanced bone turn over e.g. Paget`s disease of bone.

Gallium Nitrate is primarily indicated in conditions like Hypercalcemia due to malignancy, and can also be given in adjunctive therapy as an alternative drug of choice in Bladder carcinoma, Bone (pagets) disease, Bone metastasis, Non-Hodgkin's lymphoma, Postmenopausal disorders.

Gallium Nitrate is contraindicated in conditions like Renal insufficiency.

Gallium Nitrate produces potentially life-threatening effects which include Acute Renal Failure, Colitis, Optic neuritis, Bloody diarrhea, Ocular pain, Decreased visual acuity. which are responsible for the discontinuation of Gallium Nitrate therapy. The signs and symptoms that are produced after the acute overdosage of Gallium Nitrate include Nausea, Vomiting, Renal insufficiency. The symptomatic adverse reactions produced by Gallium Nitrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Fever, Tachycardia, Tinnitus, Hypotension, Muscle cramps, Peripheral neuropathy, Metallic taste, Anemia, Leukopenia, Hypophosphatemia, Hypocalcemia, Tetany, Mild respiratory alkalosis, Pleural effusion, Decreased hearing, Rash, Tachycardia, Lower extremity edema.

It should be use with caution in patients with with impaired renal function. Administer to a pregnant woman only if clearly needed because it is category C drug. Closely monitor renal function and serum calcium during gallium nitrate therapy patient should be well hydrated and have good renal out put before starting the infusion.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

IV (The dose is based on body size and must be determined by your doctor. Gallium nitrate is injected slowly into a vein over 24 hours, for five days. The dose may be repeated in two to four weeks.) —

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

No data regarding the interactions of Gallium Nitrate was found.

Inf (reconstituted) Store at room temperature or refrigerator. Use within 7 days if refrigerated and within 48 hrs if kept at room temperature. Inj Store at room temperature.