Medicines/Generics/Glibenclamide

Glibenclamide

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Glibenclamide is a oral hypoglycemic agent. Glibenclamide is used in the treatment of non-insulin dependent diabetes. Glibenclamide is used in conjunction with proper diet and exercise to decrease blood sugar levels.

Indications

Glibenclamide is primarily indicated in conditions like Non-insulin dependent diabetes mellitus, Softening and dilatation of cervix before mechanical cervical dilatation.

Contraindications

Glibenclamide is contraindicated in conditions like Renal failure,Liver diseases,Diabetic coma,Impaired renal function,Insulin dependent diabetes mellitus.

Side Effects

The severe or irreversible adverse effects of Glibenclamide, which give rise to further complications include Thrombocytopenia, Cholestatic jaundice, Aplastic anemia, Hemolytic anemia, Leucopenia, Agranulocytosis, Pancytopenia. Glibenclamide produces potentially life-threatening effects which include Hypersensitivity reactions, Renal failure, Hypoglycemia, Pneumonia. which are responsible for the discontinuation of Glibenclamide therapy. The signs and symptoms that are produced after the acute overdosage of Glibenclamide include Coma, Hypoglycemia, Cerebral damage.The symptomatic adverse reactions produced by Glibenclamide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, GI upset, Heart burn, Allergic skin reactions, Hepatitis, Hypoglycemia.

Warnings

During treatment with glibenclamide, compliance to diet and regular tablet intake are of utmost importance to preserve the efficacy of treatment and to avoid unwanted changes in the blood sugar levels. Hypoglycemic reactions may provoked by overdosage of glibenclamide, interacting drugs , dietary errors (omitting meals), the signs of it being headache, irritability, restlessness, profuse sweating, insomnia, tremor, impairment of performance and alertness, such hypoglycemic episodes are nearly always promptly relieved by the intake of sugar.

High Risk Groups

Drug should not be given to Pregnant Mothers, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

2.5 mg (2.5 (2.5)) 24 hourly PO — Dose may be increased by 2.5 mg.

Child Dosage

( ) — Not recommended in this age group

Neonatal Dosage

( ) — Not recommended in this age group

Drug Interactions

Glibenclamide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBosentanPlasma concentration of both drugs reduced when Bosentan given with Glibenclamide; avoid concomitant use.MajorDiazoxideDiazoxide antagonises hypoglycaemic effect of antidiabetics.LinagliptinLinagliptin increases AUC and Cmax of Glibencamide by 14%LornoxicamMay increase the hypoglycaemic effect of sulphonylurea.Metformin (HCl)MethylprednisoloneSteroids (e.g Methylprednisolone) induced hyperglycemia may partially antagonize the effect of hypoglycemic drugs (e.g Glibenclaimide)Propranolol (HCl)Tincture MyrrhTincture Myrrh may increase the level of suger in blood if taking myrrh by mouth & may interfere with the effectiveness of medications used for the treatment of diabetes.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Store Below 20°C. Tab Store in a well closed container, Below 40°C.

Available Brands in Pakistan

31 active brands listed alphabetically.

Glibenclamide

Available Brands in Pakistan

BEMIDE

BENCLAMIDE

BENIL

DESUGAR

DIABETA

DIABINIL

DIAMIN

DICON

EUGLUCON

GLABINOL

GLAONIL

GLIBETIDE

GLIBOMET

GLICAM

GLICON

GLIFEN

GLIMET

GLIMME

GLUCOBAN

GLUCOMET

GLUCOMET PLUS

GLUCOVANCE

GLUKIL

IBENESE

JACLAMIDE

METCON

METCON PLUS

PHARMIDE

PLIGLIBEN

SEMI GLICON

SEMI METCON