Medicines/Generics/Gliclazide

Gliclazide

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Gliclazide is a sulfonyl urea compound. Gliclazide is oral hypoglycemic agent and effective in the treatment of non-insulin dependent diabetes. Gliclazide is used in conjunction with proper diet and exercise to decrease blood sugar levels. It also reduces the cardiovascular complications of diabetic patient.

Indications

Gliclazide is primarily indicated in conditions like Diabetes mellitus type-II.

Contraindications

Gliclazide is contraindicated in conditions like IDDM, Ketosis.

Side Effects

The severe or irreversible adverse effects of Gliclazide, which give rise to further complications include GI symptoms, Liver problems, Dermatological reactions, Hypoglycemia. Gliclazide produces potentially life-threatening effects which include Hypoglycemia, Brain damage, which are responsible for the discontinuation of Gliclazide therapy. The signs and symptoms that are produced after the acute overdosage of Gliclazide include Hypoglycemia, Cerebral edema. The symptomatic adverse reactions produced by Gliclazide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Skin rashes, GI upset, Abdominal pain

Warnings

Should not be used in severe renal impairment. Not recommended in pregnancy.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

40 to 80 mg (60 (60)) 24 hourly PO — Max dose 320 mg. doses > 160 mg given in 2 divided doses.

Child Dosage

( ) — Not recommended in this age group

Neonatal Dosage

( ) — Not recommended in this age group

Drug Interactions

Gliclazide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAspirinClofibrateDiazoxidePhenylbutazone RifampicinSulphamethizoleGliclazide may be displaced from protein binding sites or their metabolism may be inhibited by some sulfonamides, resulting in increased or prolonged effects or toxicity.Dosage adjustments may be necessary during and after sulfonamide therapy These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Tab Store in a well closed container, Below 40°C. Protect from Sunlight.

Available Brands in Pakistan

41 active brands listed alphabetically.

Gliclazide

Available Brands in Pakistan

APTIZID

AZIDE

DB-ZIDE

DIABETRON

DIABO

DIAGLIC

DIAMICRON

DIAMICRON-MR

DIAMIDE

DIANEXT

DIARON

DICLAZIDE

DIOCID

DIOZIDE

FYMICRON

GETZID MR

GLARE TAB

GLAZE

GLAZID

GLICLAMED

GLICLAZIDE

GLICOTRON

GLIDE

GLIMICRON

GLIMIN

GLIMIN FORTE

GLINEXT

GLINEXT

GLIZID-80

GLUCOFEND

MACAZID

NIDONIL

NODIBET

PROTECT

SCICON MR

SUCRONIL

SUGCON

TAGAMICRON

TRYMICRON MR

ZACLAZIDE

ZENZIDE