Medicines/Generics/Glyceryl Trinitrate

Glyceryl Trinitrate

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Glyceryl Trinitrate is a vasodilator (expands the blood vessels) Glyceryl Trinitrate is used for symptomatic treatment of angina to treat cardiac failure and during hypotensive or cardiac surgery to prevent myocardial infarction.

Indications

Glyceryl Trinitrate is primarily indicated in conditions like Anal fissure, Angina pectoris, Cardiac failure, Cardiopulmonary edema, Long-term treatment of healed reflux esophagitis, Moderate to severe reflux esophagitis, Myocardial infarction, esophageal spasm, Postoperative hypertension, Prinzmetal's angina, Prophylaxis of angina, Unstable angina.

Contraindications

Glyceryl Trinitrate is contraindicated in conditions like Glaucoma, Hypovolemia, Cardiac temponade, Cardiomyopathy, Cor pulmonale, Mitral valve prolapse, Raised intracranial pressure.

Side Effects

The severe or irreversible adverse effects of Glyceryl Trinitrate, which give rise to further complications include Tachycardia, Bradycardia, Collapse. The signs and symptoms that are produced after the acute overdosage of Glyceryl Trinitrate include Hypotension, Flushing, Tachycardia, Coma, Palpitations, Metabolic acidosis, Headache, Cardiovascular collapse, Syncope, Neurologic deficit, Methemoglobinemia, Increased intracranial pressure, Hypoxia, Cyanosis. The symptomatic adverse reactions produced by Glyceryl Trinitrate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Nausea, Vomiting, Restlessness, Palpitation, Abdominal pain, Vertigo, Urinary incontinence, Contact dermatitis, Syncope, Fecal incontinence, Orthostatic hypotension.

Warnings

Excessive use of glyceryl trinitrate may cause headache, so reduce the dose & use analgesics (painkiller). Patients with gastrointestinal (GI) hypermotility or malabsorption syndrome should take oral or sublingual sustained release capsules rather than tablets. In terminating treatment of angina, gradually reduced the dose in order to avoid withdrawal reactions. It should not be used in patients with severe hypotension, hypovolemia marked anemia, heart failure due to obstruction, raised intracranial pressure or angle closure glaucoma. It should be used with caution in patients with impaired kidney or liver function or hypothyroidism. Hypothermia, cerebrovascular disease disease lung disease, lung disease or cor pulmonale pregnancy, lactation mitral value proloapse syncope.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

0.5 to 1 mg (0.75 (0.75)) As recommended. Sublingual — As required glyceryl trinitrate can be repeated every 3 minutes untill pain relieves. 5 to 10 mg (7.5 (7.5)) As recommended. Topical — glyceryl trinitrate 2% ointment can be used every 4-6 hours as required

Child Dosage

( ) — Not recommended in this age group

Neonatal Dosage

( ) — Not recommended in this age group

Drug Interactions

Glyceryl Trinitrate is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAlprostadilEnhanced hypotensive effects when alprostadil given with Nitrates (e.g Glyceryl trinitrate).ApomorphineSublingual apomorphine enhances hypotensive effecs of nitrates.AspirinAtropine (Sulphate)Ergotamine (Tartrate)glyceryl trinitrate increase oral bioavailibilty and plasma concentration of dihydroergotamine in patients with orthostatic hypotensionHeparin (Na) and Heparin (Cl)Imipramine (HCl)Quinagolide (HCl)Rauwolfia ReserpineReserpine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Store Between 15°C-30°C.

Available Brands in Pakistan

30 active brands listed alphabetically.

Glyceryl Trinitrate

Available Brands in Pakistan

ANG

ANGILINGUAL

ANGINOR

ANGIOCARD

ANGIOCARD

ANGISED

ANGITRYL

CARDNIT

CORNIT

DEPONIT

GLYRATE-SR

GLYRATE-SR

GLYTRIN

LIFSAVE

N-GLYCRIN

NIGLYS

NITRIL

NITRIL-MR

NITROCINE

NITROLINGUAL

NITROLINGUAL RETARD

NITROMINT

NITROMINT RETARD

NITRONAL

NITROSCOT

NITROSUST

SUSCARD BUCCAL

SUSTAC

TRYGIL

WEBSER