Gonadorelin (HCl)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Gonadorelin (HCl) is the mono or dihydrochloride salt of gonadorelin which is a synthetic form of hypothalamic gonadotrophin-releasing hormone, structurally identical to the natural hormone. Gonadorelin (HCl) is used in the treatment of amenorrhea and infertility due to ovarian hormone deficiency.
Indications
Gonadorelin (HCl) is primarily indicated in conditions like Amenorrhea, Infertility, Precocious puberty, Prostate cancer.
Contraindications
Gonadorelin (HCl) is contraindicated in conditions like Genital bleeding,Ovarian failure.
Side Effects
Gonadorelin (HCl) produces potentially life-threatening effects which include Anaphylactic reactions, which are responsible for the discontinuation of Gonadorelin (HCl) therapy. The symptomatic adverse reactions produced by Gonadorelin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Pruritus, Hypersensitivity reactions, Skin rash, Flushing, Thrombophlebitis, Light headedness, Septicemia, Local swelling, Abdominal discomfort, Irritation at injection site, Increase menstrual bleeding.
Warnings
No withdrawal period or milk discard time is required when used according to labeling.
High Risk Groups
No withdrawal period or milk discard time is required when used according to labeling.
Adult Dosage
0.357 to 1.429 ug/kg (0.89 (0.893)) As recommended. IV — As Required
0.357 to 1.429 ug/kg (0.89 (0.893)) As recommended. SC — As Required
Scraped Dose — For the treatment of ovarian follicular cysts in lactating dairy cows, beef cows, and replacement dairy and beef heifers : Administer 2 mL of FACTREL Injection as a single intramuscular injection.
For use with LUTALYSE (dinoprost tromethamine injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows : Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework:
● Administer the first dose of FACTREL Injection (2-4 mL) at Day 0
● Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine injection) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection.
● Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection.
● Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices.
Below are three examples of treatment regimens for FTAI that fit within the dosage regimen framework described immediately above:
Child Dosage
Not licensed for used in children under 1 year. ( ) —
Neonatal Dosage
12.5 ug/kg (12 (12.5)) As recommended. Intravenous —
12.5 ug/kg (12 (12.5)) As recommended. Subcutaneous —
Drug Interactions
No data regarding the interactions of Gonadorelin (HCl) was found.
Storage
Inj Store in a well closed container. Refrigeration is recommended. Protect from Sunlight.
Available Brands in Pakistan
No brands are recorded for this generic.