Hirudin
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Hirudin is a protein consists of 65-amino-acid, that is a direct inhibitor of thrombin. It has been extracted from leeches and this form is used in various topical preparations. Whereas, the recombinant form includes Lepirudin and Desirudin. Lepirudin is used as an anticoagulant in patients with heparin induced thrombocytopenia, who require parenteral antithrombotic treatment. Recombinant forms may also be used in myocardial infarction (MI) and unstable angina.
Indications
Hirudin is primarily indicated in conditions like Deep vein thrombosis, Hemodialysis, Heparin induced thrombocytopenia, Thrombolytic therapy in acute myocardial infarction, Unstable angina.
Contraindications
Hirudin is contraindicated in conditions like Hypersensitivity, Bleeding diathesis.
Side Effects
Hirudin produces potentially life-threatening effects which include Hemorrhage. which are responsible for the discontinuation of Hirudin therapy. The symptomatic adverse reactions produced by Hirudin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Allergic reactions, Acute urticaria.
Warnings
Doses of Hirudin should be reduced in patient with renal impairment. It must be administered parenterally and is monitored by the PTT.
High Risk Groups
Drug should not be given to Pregnant Mothers. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
No adult dosage information is recorded for this medicine yet.
Child Dosage
0.1 mg/kg/hour (0.1 (0.1)) 2 hourly Bolos — For myocardial infarction.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Hirudin was found.
Storage
No storage information is recorded for this medicine yet.
Available Brands in Pakistan
No brands are recorded for this generic.