Hydroflumethiazide

Hydroflumethiazide is a diuretic. It increases urination. Hydroflumethiazide is used in hypertension to lower the high blood pressure and also used to treat fluid overload.

Hydroflumethiazide is primarily indicated in conditions like Disorders of calcium balance, Edema, Heart failure, Hypertension, Edema, and can also be given in adjunctive therapy as an alternative drug of choice in Diabetes insipidus.

Hydroflumethiazide is contraindicated in conditions like Diabetes mellitus, Hypokalemia.

The severe or irreversible adverse effects of Hydroflumethiazide, which give rise to further complications include Thrombocytopenia, Pancreatitis, Cholestatic jaundice, Photosensitivity, Acute interstitial pulmonary edema, Skin rashes, Atherosclerosis, Necrotizing vasculitis. Hydroflumethiazide produces potentially life-threatening effects which include Hyponatremia, Hypokalemia, Cardiac arrhythmias, Abnormal lipid profile, Hypoplastic Anemia. which are responsible for the discontinuation of Hydroflumethiazide therapy. The signs and symptoms that are produced after the acute overdosage of Hydroflumethiazide include Hypotension, Volume depletion, Hypokalemia, Renal failure, Hyponatremia. The symptomatic adverse reactions produced by Hydroflumethiazide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Thirst, Headache, Nausea, Gout, Impotence, Polyuria, Night cramps.

Thiazide diuretics increase sensitivity to sunlight, so avoid prolonged sun exposure, use a sunscreen and wear protective clothing. This medication should be used during pregnancy or lactation only if clearly needed. It should be used with caution in patients with gout or diabetes or any allergies especially to sulfa medications. Avoid any drugs that increase heart rate or cause excitation like decongestants (present in cough or cold products) because it may counter-act the blood pressure medicine.

Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.357 mg/kg (0.36 (0.357)) As recommended. PO — Initially for Once 0.357 to 2.857 mg/kg (1.6 (1.607)) 24 hourly PO — Maintenance, As Required

1 mg/kg (1 (1)) 24 hourly Oral — -

1 mg/kg (1 (1)) 24 hourly Oral — -

Hydroflumethiazide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAlcuronium (Cl)AllopurinolDigoxinHydroflumethiazide may enhance the adverse/toxic effect of Digoxin. This by increasing the risk of hypokalemia. ModerateMonitor for increased toxic effects of Digoxin if Hydroflumethiazide is initiated or the dose is increased. The use of a potassium-sparing diuretic might be considered to minimize potassium loss. Likewise, potassium supplementation, along with careful monitoring of serum potassium and possibly Digoxin concentrations, might be helpful.LithiumPancuronium (Br)Probenecidthiazide diuretics inhibits the uricosuric effects of probencidQuinidineTubocurarine (Cl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Tab Store Below 40°C. Protect from Sunlight and Moisture.