Iotroxate (Meglumine)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Iotroxate (Meglumine) is iodinated, water soluble radiological contrast agent for intravenous cholangiography and cholecystography. Chemically Iotroxate (Meglumine) is N-methylglucamino-3,3-(3, 6, 9-trioxaundecanedioyldi-imino) bis (2, 4, 6-tri-iodobenzoate). Iotroxate (Meglumine) is prepared by chemical synthesis and not available in any combination preparations.
Indications
Iotroxate (Meglumine) is primarily indicated in conditions like Cholangiography, Cholecystography, Failure of oral cholecystography, Postcholicystectomy biliary symptoms, Suspected cholidocholithiasis in non-icteric.
Contraindications
Iotroxate (Meglumine) is contraindicated in conditions like Asthma, Myeloma, Atopy, Hypersensitivity.
Side Effects
The severe or irreversible adverse effects of Iotroxate (Meglumine), which give rise to further complications include Nephrotoxicity, Hepatotoxicity, Sickle crises in sicklers, Hypertensive crises in existing pheochromocytoma. Iotroxate (Meglumine) produces potentially life-threatening effects which include Anaphylactoid reactions, circulatory collapse, Bronchospasm, Acute Renal Failure, Angioneurotic edema, Acute renal failure, Obstructive nephropathy, Circulatory collapse. which are responsible for the discontinuation of Iotroxate (Meglumine) therapy. The symptomatic adverse reactions produced by Iotroxate (Meglumine) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Restlessness, Sedation, Flushing, Nausea and vomiting, Faintness.
Warnings
Iotroxate should be administered with great caution in patients with asthma and history of allergy, and should be avoided to patients with known hypersensitivity to iodine or contrast media. Caution is needed in patients with severe hepatic (liver) or renal impairment or who may be at a risk of renal failure. Dehydration patients should have their fluid and electrolyte balance corrected before administration of contrast medium. It should be used with extreme caution in patients with hypertension, cardiac disease, pheochromocytoma, sickle-cell anemia or hypothyroidism. Avoid use during pregnancy.
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
10 mg/kg.min (10 (10)) As recommended. IV Inf — Once,upto 15 min.,as required
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Iotroxate (Meglumine) was found.
Storage
IV inf Protect from Sunlight and Heat.
Available Brands in Pakistan
No brands are recorded for this generic.