Ipilimumab

Ipilimumab ( Yervoy ) is an immunotherapy used to treat specific cancers, including melanoma, non-small cell lung cancer (NSCLC) , pleural mesothelioma , esophageal cancer, kidney cancer (RCC), liver cancer , or colorectal cancer . Ipilimumab can be used alone or combined with another cancer medicine such as Opdivo (nivolumab). Ipilimumab is a monoclonal antibody that blocks a protein (antigen) that can stop your immune system from working properly and attacking cancer cells. When ipilimumab has blocked the protein (CTLA-4) the immune system is able to find and kill the cancer cells. Ipilimumab is from the class of medicines called immune checkpoint inhibitors, and because it blocks the T-lymphocyte antigen 4 (CTLA-4), it is called a CTLA-4 inhibitor. Ipilimumab will be given to you as an infusion in your arm every 3 to 6 weeks, depending on your treatment plan.

Ipilimumab ( Yervoy ) is an immunotherapy used to treat specific cancers, including melanoma, non-small cell lung cancer (NSCLC) , pleural mesothelioma , esophageal cancer, kidney cancer (RCC), liver cancer , or colorectal cancer . Ipilimumab can be used alone or combined with another cancer medicine such as Opdivo (nivolumab). Ipilimumab is a monoclonal antibody that blocks a protein (antigen) that can stop your immune system from working properly and attacking cancer cells. When ipilimumab has blocked the protein (CTLA-4) the immune system is able to find and kill the cancer cells. Ipilimumab is from the class of medicines called immune checkpoint inhibitors, and because it blocks the T-lymphocyte antigen 4 (CTLA-4), it is called a CTLA-4 inhibitor. Ipilimumab will be given to you as an infusion in your arm every 3 to 6 weeks, depending on your treatment plan.

You should not receive this medicine if you are allergic to the active ingredient ipilimumab or any of the inactive ingredients. To make sure this medicine is safe for you, tell your doctor if you have ever had: liver problems; an autoimmune disorder ( lupus , sarcoidosis, Crohn's disease , ulcerative colitis ); an organ transplant or stem cell transplant; or a nerve-muscle disorder, such as myasthenia gravis, or Guillain-Barre syndrome. Ipilimumab is not approved for use by anyone younger than 12 years old, and for some types of cancer, it is used only in adults.

The severe or irreversible adverse effects of Ipilimumab, which give rise to further complications include Hepatotoxicity, Abdominal pain, Elevated SGPT & SGOT, Hepatotoxicity, Enterocolitis, Aseptic meningitis, Hypophysitis.Ipilimumab produces potentially life-threatening effects which include Adrenal Insufficiency, Stevens Johnson syndrome, skin rash, GI perforation, Stevens Johnson syndrome, Severe diarrhea, hypothyroidism, Adrenal insufficiency, Toxic epidermal necrolysis, hyperthyroidism, GI hemorrhage, hypopituitarism. which are responsible for the discontinuation of Ipilimumab therapy.The symptomatic adverse reactions produced by Ipilimumab are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fatigue, Nausea, Vomiting, Diarrhea, Abdominal pain, Rashes, Pruritus, Colitis, Hemolytic anemia, Dermatitis, Decreased appetite, Pneumonitis, Hepatitis, Iritis, Pancreatitis, Uveitis, esinophilia, lipase elevation, glomerulonephritis, amylase elevation, oxygen failure.

Ipilimumab is a medicine that may treat certain cancers by working with your immune system. Ipilimumab can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You may have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended. Some of these problems may happen more often when ipilimumab is used in combination with nivolumab. Call your doctor at once if you have: chest pain, cough, shortness of breath, vision changes, severe muscle pain or weakness, diarrhea and severe stomach pain, blood in your stools, little or no urinating, swelling, bruising, or bleeding, dark urine, yellowing of the skin or eyes, confusion, hallucinations, a seizure, skin blistering, or a hormonal disorder (frequent headaches, feeling light-headed, increased thirst or urination, feeling cold, weight gain or loss).

Ipilimumab is a medicine that may treat certain cancers by working with your immune system. Ipilimumab can cause your immune system to attack normal organs and tissues in any area of your body and can affect the way they work. These problems can sometimes become severe or life-threatening and can lead to death. You may have more than one of these problems at the same time. These problems may happen anytime during treatment or even after your treatment has ended. Some of these problems may happen more often when ipilimumab is used in combination with nivolumab. Call your doctor at once if you have: chest pain, cough, shortness of breath, vision changes, severe muscle pain or weakness, diarrhea and severe stomach pain, blood in your stools, little or no urinating, swelling, bruising, or bleeding, dark urine, yellowing of the skin or eyes, confusion, hallucinations, a seizure, skin blistering, or a hormonal disorder (frequent headaches, feeling light-headed, increased thirst or urination, feeling cold, weight gain or loss).

3 mg/kg (3 (3)) As recommended. IV — Administer IV over 90 minute period. patient should recieve entire regimen in dilution (4 doses) as tolerated. assessment of tumor response should be conducted only after therapy. LFT & TFT should be evaluated at baseline before each dose of ipilimumab. must not be administer as an IV push or bolus. can be given as a dilution of NaCl 9mg/ml (0.9%) solution for injection or glucose 50mg/ml (5%) solution for injection to concentration between 1 & 4 mg/ml.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Some medications interact with ipilimumab, so it is important to tell your doctor about any medicines that you are currently taking, or if you start or stop any medicine while you are having cancer treatment. Also, tell your doctor about any over-the-counter medicines, vitamins, minerals, or herbal products that you take.

injection Store in refrigerator. Do not Freeze. Protect from Sunlight.