L-Ornithine L-Aspartate

L-arginine is classified as a nonessential amino acid but may be considered essential or semiessential under conditions of stress when the capacity of endogenous arginine synthesis is exceeded, including during periods of growth (ie, childhood, pregnancy) or trauma (eg, liver disease, severe sepsis, wound healing, cancer). Morris 2017 , Rodríguez 2008 , Wu 2009 Normal serum levels of L-arginine range from 50 to 150 mcM. Rodríguez 2008 Because most arginine in the typical American diet is obtained from meat and fish, which provide about 5.5 g daily, vegetarians may be at risk for arginine deficiency. Cheng 2001 L-arginine's suggested metabolic and physiologic roles in the body include the following: building block of proteins; precursor of nitric oxide; induction of vasodilation; synthesis of creatine; reduction in xanthine oxidase activity; induction of bone and tendon formation and skin epithelization; simulation of energy metabolism through maintenance of adenosine triphosphate levels; simulation of the release of growth hormone and prolactin; simulation of insulin synthesis and secretion; improvement in immune defense function; neuroprotective effects; reduction in growth of tumors; improvement in kidney function; reduction in platelet aggregation; improvement in sperm motility and production; and prevention of leukocyte adhesion to the vascular endothelium and leukocyte migration into the vascular wall. Hristina 2014 L-arginine also plays an important role in the detoxification of ammonia from the body. Calabrò 2014 Nitric oxide is produced by a variety of animal and human cells and is involved in many physiological and pathophysiological processes. Luiking 2010 L-arginine is a substrate for 4 enzymes: nitric oxide synthases, arginases, arginine glycine amidinotransferase, and L-arginine decarboxylase. Rodríguez 2008 Nitric oxide, along with L-citrulline, is generated from L-arginine metabolism by the nitric oxide synthase enzymes. Rodríguez 2008 , Schwedhelm 2008 Arginases metabolize L-arginine to L-ornithine and urea. Morris 2017 , Rodríguez 2008 Following oral administration, L-arginine undergoes presystemic (ie, via GI flora) and systemic (ie, via gut and liver arginases) elimination. Schwedhelm 2008 Most studies affirm stereospecificity of nitric oxide synthase for L-arginine, but trial results in steroid-naive patients with asthma show concentrations of exhaled nitric oxide to be similar for patients administered either L- or D-arginine, suggesting an alternative mechanism of action. Chambers 2001 L-arginine is a vital amino acid required for the survival of certain parasites, such as Leishmania spp., the causative agent of leishmaniasis. Wanasen 2008

L-arginine is classified as a nonessential amino acid but may be considered essential or semiessential under conditions of stress when the capacity of endogenous arginine synthesis is exceeded, including during periods of growth (ie, childhood, pregnancy) or trauma (eg, liver disease, severe sepsis, wound healing, cancer). Morris 2017 , Rodríguez 2008 , Wu 2009 Normal serum levels of L-arginine range from 50 to 150 mcM. Rodríguez 2008 Because most arginine in the typical American diet is obtained from meat and fish, which provide about 5.5 g daily, vegetarians may be at risk for arginine deficiency. Cheng 2001 L-arginine's suggested metabolic and physiologic roles in the body include the following: building block of proteins; precursor of nitric oxide; induction of vasodilation; synthesis of creatine; reduction in xanthine oxidase activity; induction of bone and tendon formation and skin epithelization; simulation of energy metabolism through maintenance of adenosine triphosphate levels; simulation of the release of growth hormone and prolactin; simulation of insulin synthesis and secretion; improvement in immune defense function; neuroprotective effects; reduction in growth of tumors; improvement in kidney function; reduction in platelet aggregation; improvement in sperm motility and production; and prevention of leukocyte adhesion to the vascular endothelium and leukocyte migration into the vascular wall. Hristina 2014 L-arginine also plays an important role in the detoxification of ammonia from the body. Calabrò 2014 Nitric oxide is produced by a variety of animal and human cells and is involved in many physiological and pathophysiological processes. Luiking 2010 L-arginine is a substrate for 4 enzymes: nitric oxide synthases, arginases, arginine glycine amidinotransferase, and L-arginine decarboxylase. Rodríguez 2008 Nitric oxide, along with L-citrulline, is generated from L-arginine metabolism by the nitric oxide synthase enzymes. Rodríguez 2008 , Schwedhelm 2008 Arginases metabolize L-arginine to L-ornithine and urea. Morris 2017 , Rodríguez 2008 Following oral administration, L-arginine undergoes presystemic (ie, via GI flora) and systemic (ie, via gut and liver arginases) elimination. Schwedhelm 2008 Most studies affirm stereospecificity of nitric oxide synthase for L-arginine, but trial results in steroid-naive patients with asthma show concentrations of exhaled nitric oxide to be similar for patients administered either L- or D-arginine, suggesting an alternative mechanism of action. Chambers 2001 L-arginine is a vital amino acid required for the survival of certain parasites, such as Leishmania spp., the causative agent of leishmaniasis. Wanasen 2008

L-Ornithine L-Aspartate is contraindicated in conditions like Pregnancy, Renal insufficiency.

The symptomatic adverse reactions produced by L-Ornithine L-Aspartate are more or less tolerable and if they become severe, they can be treated symptomatically, these include Transient nausea and vomiting.

In patient with severe renal insufficiency blood urea, and serum creatinine must be monitored regularly, serum creartinine value exceeding 3gm/ml is regarded as reference value.

Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

300 mg (300 (300)) 12 hourly IV — For 3-4 Weeks 600 mg (600 (600)) 12 hourly PO —

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Nitrates: Caution is warranted in patients concomitantly using L-arginine supplementation and nitrates. L-arginine may potentiate the effects of isosorbide mononitrate and other nitric oxide donors, such as glyceryl trinitrate (ie, nitroglycerin) and sodium nitroprusside. Insulin: Caution is warranted in patients using insulin concomitantly with L-arginine; effects on insulin are unpredictable. Cholesterol-lowering drugs: Caution is warranted in patients using cholesterol-lowering drugs concomitantly with L-arginine; effects on cholesterol-lowering drugs are unpredictable.

No storage information is recorded for this medicine yet.