Lamotrigine

Lamotrigine is an anti-epileptic medication, also called an anticonvulsant. Lamotrigine is used to treat epileptic seizures in adults and children and is used for bipolar disorder ( manic depression ) in adults to delay mood episodes. Immediate-release lamotrigine can be used in children as young as 2 years old when it is given as part of a combination of seizure medications. However, this form should not be used as a single medication in a child or teenager who is younger than 16 years old. Extended-release lamotrigine is for use only in adults and children who are at least 13 years old. Lamotrigine oral suspension (Subvenite) was approved on September 16, 2025, and is recommended for young children and those who have difficulty swallowing tablets.

Lamotrigine is an anti-epileptic medication, also called an anticonvulsant. Lamotrigine is used to treat epileptic seizures in adults and children and is used for bipolar disorder ( manic depression ) in adults to delay mood episodes. Immediate-release lamotrigine can be used in children as young as 2 years old when it is given as part of a combination of seizure medications. However, this form should not be used as a single medication in a child or teenager who is younger than 16 years old. Extended-release lamotrigine is for use only in adults and children who are at least 13 years old. Lamotrigine oral suspension (Subvenite) was approved on September 16, 2025, and is recommended for young children and those who have difficulty swallowing tablets.

You should not take lamotrigine if you are allergic to it or any of the inactive ingredients. Lamotrigine may cause a severe or life-threatening skin rash, especially in children and in people who take a very high starting dose, or those who also take valproic acid (Depakene) or divalproex (Depakote). Tell your doctor if you have ever had: a rash or allergic reaction after taking another seizure medication; kidney or liver disease ; heart problems such as heart block or irregular heartbeats; depression, suicidal thoughts or actions; or meningitis (inflammation of the tissue that covers the brain and spinal cord) after taking lamotrigine. Some people have thoughts about suicide while taking lamotrigine. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms. Do not start or stop taking seizure medication during pregnancy without your doctor's advice. Having a seizure during pregnancy could harm both mother and baby. Tell your doctor right away if you become pregnant. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lamotrigine on the baby. Birth control pills can make lamotrigine less effective, resulting in increased seizures. Tell your doctor if you start or stop using birth control pills. Your lamotrigine dose may need to be changed. It may not be safe to breastfeed while using lamotrigine. Ask your doctor about any risk.

The severe or irreversible adverse effects of Lamotrigine, which give rise to further complications include Ataxia, Thrombocytopenia, Aplastic anemia, Stevens Johnson syndrome, Epidermal necrolysis, Lymphadenopathy, Angioedema, Leucopenia, Neutropenia, Nystagmus, Extrapyramidal symptoms, Pancytopenia, Tremors, Hepatic failure, Facial edema, Choreoathetosis. The symptomatic adverse reactions produced by Lamotrigine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Drowsiness, Irritability, Ataxia, Nausea, Fever, Anxiety, Insomnia, Blurred vision, Maculopapular rash, Rashes, Confusion, Sedation, Malaise, Depression, Tremor, Diplopia, Arthralgia, Somnolence, Agitation, Liver dysfunction, Aggression.

Lamotrigine should be used with caution in patients with any pre-existing illness, especially of the heart, liver or kidneys or if have any drug allergy. Lamotrigine must be used with caution in patients under the age of 16 years due to insufficient information of use in this age group. Sunscreen or protective clothing is recommended to protect against possible severe rash triggered by sunlight. It should be used with caution while operating machinery or engaging in activities requiring alertness. Limit alcohol intake while taking this drug. It should be used only if clearly needed during pregnancy. The dose of lamotrigine in treatment of epilepsy with other AEDs should be gradually decreased over a period of 2 weeks because abrupt withdrawal of lamotrigine may provoke rebound seizures, unless safety concerns (e.g., rash) require an abrupt withdrawal. Physician should consider the possibility of a drug reaction in children that develop symptoms of rash and fever during the first eight weeks of therapy. All patients who develop a rash should be promptly evaluated and lamotrigine withdrawn immediately unless the rash is clearly not drug related.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

25 mg (25 (25)) 24 hourly PO — Scraped Dose — Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. Taking too much lamotrigine at the start of treatment may increase your risk of a severe life-threatening skin rash. You may need frequent blood tests to help your doctor make sure you are taking the right dose. Extended-release and immediate-release lamotrigine may be used for different conditions. Always check your refills to make sure you have received the correct size, color, and shape of tablet. Avoid medication errors by using only the form and strength your doctor prescribes. If you switch to lamotrigine from another seizure medicine, carefully follow your doctor's instructions about the timing and dosage of your medicine. Swallow the tablet whole and do not crush, chew, or break it. Read and carefully follow any Instructions for Use provided with the orally disintegrating or dispersible tablets. Ask your doctor or pharmacist if you do not understand these instructions. Lamotrigine oral suspension (Subvenite) may be taken with or without food. The pharmacy should provide you with an oral dosing syringe or dosing cup that is needed to correctly measure your dose . Do not use a household teaspoon or tablespoon. Do not stop using lamotrigine suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor's instructions about tapering your dose. In case of emergency, wear or carry medical identification to let others know you use seizure medication. Lamotrigine may affect a drug-screening urine test, and you may have false results. Tell the laboratory staff that you use lamotrigine. Store at room temperature away from light and moisture.

300 ug (300 (300)) As recommended. Oral — Initial, repeated on alternate days 600 ug (600 (600)) 24 hourly Oral — Maintenance, As Required

5 mg/kg (5 (5)) As recommended. Oral — Initial, repeated on alternate days 5 to 1 mg/kg (3 (3)) 24 hourly Oral — Maintenance, As Required

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Tell your doctor if you take any of the following medication, as these drugs may affect Lamictal; anti-epileptic medications including valproic acid, divalproex sodium, carbamazepine, phenytoin, phenobarbital, or primidone; antibiotics, such as rifampin; birth control pills called oral contraceptives; or human immunodeficiency virus (HIV) medications including lopinavir/ritonavir or atazanavir/lopinavir Other drugs may interact with lamotrigine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Tab Store in a well closed container, Below 40°C. Protect from Sunlight and Heat.