Lepirudin
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Lepirudin is a recombinant Hirudin which is used as anticoagulant in patients with heparin-induced thrombocytopenia who require parenteral antithrombotic treatment. Lepirudin is being investigated in arterial thrombo-embolic disorders such as angina and MI (myocardial infarction).
Indications
Lepirudin is primarily indicated in conditions like Endometrial thinning before intra-uterine surgery.
Contraindications
Lepirudin is contraindicated in conditions like Pregnancy, Breast feeding.
Side Effects
The severe or irreversible adverse effects of Lepirudin, which give rise to further complications include Bleeding, Hematoma, Hypersensitivity. Lepirudin produces potentially life-threatening effects which include Intracranial hemorrhages. which are responsible for the discontinuation of Lepirudin therapy. The signs and symptoms that are produced after the acute overdosage of Lepirudin include Bleeding complications. The symptomatic adverse reactions produced by Lepirudin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Fever, Hematuria, Allergic reactions, Rectal bleeding, Anemia.
Warnings
Renal impairment; hepatic impairment; recent bleeding or risk of bleeding including recent puncture of large vessels, organ biopsy, recent major surgery, stroke, hemorrhagic diathesis, severe uncontrolled hypertension, bacterial endocarditis; determine activated partial thromboplastin time 4 hrs after start of treatment (or after infusion rate altered) and at least once daily thereafter.
High Risk Groups
Drug should not be given to Paediatrics, and Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
150 mcg/kg of body weight (150 (150)) As recommended. IV — Followed after initial dose
400 mcg/kg of body weight (400 (400)) As recommended. IV — Initial
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Lepirudin was found.
Storage
No storage information is recorded for this medicine yet.
Available Brands in Pakistan
No brands are recorded for this generic.