This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Levosulpiride is a substituted benzamide antipsychotic which is reported to be a selective antagonist of central dopamine (D-2, D-3 and D-4) receptors. Levosulpiride is also claimed to have mood elevating properties. Levosulpiride is used in the treatment of psychoses such as schizophrenia, anxiety disorders, vertigo and also in peptic ulceration.
Indications
Levosulpiride is primarily indicated in conditions like Anxiety, Depression, Gastro-esophageal reflux disease, Irritable bowel syndrome, Schizophrenia, Tourette's syndrome, and can also be given in adjunctive therapy as an alternative drug of choice in Peptic ulcer, Vertigo.
Contraindications
Levosulpiride is contraindicated in conditions like Epilepsy, Hyperprolactinemia, Mania, Gastrointestinal hemorrhage, pheochromocytoma, Breast feeding, Hypersensitivity to any component of product.
Side Effects
The severe or irreversible adverse effects of Levosulpiride, which give rise to further complications include Amenorrhea, Gynecomastia, Galactorrhea, Changes in libido. Levosulpiride produces potentially life-threatening effects which include Neuroleptic Malignant Syndrome, Neuroleptic malignant syndrome. which are responsible for the discontinuation of Levosulpiride therapy. The symptomatic adverse reactions produced by Levosulpiride are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sedation, Sleep disturbance, Hypotension, Gynecomastia, Galactorrhea, Agitation, Dyskinesia, Overstimulation, Hyperprolactinemia, Tardive dyskinesia.
Warnings
Should be use with caution in porphyria, renal impairment and mania and in patients receiving antihypertensive, hypnotic and analgesic drugs, because concurrent use may increase the effects of these drugs. Should be given with care to hypomanic patients.
High Risk Groups
Drug should not be given to Paediatrics, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
200 to 400 mg (300 (300)) 12 hourly PO — For the treatment of schizophrenia: upto 1200mg twice daily may be given in patients with positive symptoms or upto 800 mg in patients with mainly negative symptoms.
200 to 800 mg (500 (500)) 24 hourly IM —
25 to 25 mg (25 (25)) 8 hourly PO — For GERD, irritable bowel disease (IBS), dyspeptic syndrome, essential cephalgia.
Child Dosage
3 to 5 mg/kg (4 (4)) As recommended. PO — This is the dose for children above 14 years of age. (i.e. 3-5mg/Kg daily)
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
No data regarding the interactions of Levosulpiride was found.
Storage
No storage information is recorded for this medicine yet.
