Medicines/Generics/Lincomycin (HCl)

Lincomycin (HCl)

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Lincomycin is an antibiotic produced by a variant of Streptomyces lincolnensis. Lincomycin (HCl) is effective against gram positive bacteria. Lincomycin (HCl) is administered intramuscularly and intravenously. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular intervals of time throughout the day and night as prescribed. Lincomycin (HCl) is important to take the drug for the full time period as prescribed. If you discontinue the therapy it may result in ineffective treatment.

Indications

Lincomycin (HCl) is primarily indicated in conditions like Anaerobic infections, Chronic middle ear infection, Colitis, Impetigo, Osteomyelitis, Pneumonia.

Contraindications

Lincomycin (HCl) is contraindicated in conditions like Hypersensitivity.

Side Effects

The severe or irreversible adverse effects of Lincomycin (HCl), which give rise to further complications include Pseudomembranous colitis, Thrombocytopenia, Angioneurotic edema, Serum sickness, Granulocytopenia, Leucopenia, Neutropenia, Erythema multiforme, Glossitis, Elevated transaminases, Apnea, Vaginitis.Lincomycin (HCl) produces potentially life-threatening effects which include Syncope, Hypotension, Anaphylaxis. which are responsible for the discontinuation of Lincomycin (HCl) therapy.The symptomatic adverse reactions produced by Lincomycin (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Fever, Tinnitus, Skin rashes, Urticaria, Vertigo, Stomatitis, Esophagitis, Perianal irritation, Rectal irritation, Vaginal irritation.

Warnings

Lincomycin should be used with caution in patients with kidney or liver disease. Take appropriate measures in case of secondary infections. It should be used with caution (if contains tartrazine) in patients with aspirin hypersensitivity, because it may cause allergic reactions (including bronchial asthma).

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

500 mg (500 (500)) 8 hourly PO — With empty stomach. Frequency may be increased to 4 times if needed. 600 mg (600 (600)) 24 hourly IM — Frequency may be increased upto twice daily if needed. 600 mg (600 (600)) 12 hourly IV — Frequency may be increased upto 3 times if needed.

Child Dosage

10 to 0 mg/kg (5 (5)) As recommended. Intra Muscular — In divided doses. 30 to 0 mg/kg (15 (15)) 8 hourly Oral — 5 to 10 mg/kg (7.5 (7.5)) 8 hourly Slow IV — As Required

Neonatal Dosage

10 mg/kg (10 (10)) As recommended. Intra Muscular — Once in 24 Hours 10 mg/kg (10 (10)) 8 hourly Oral — - 5 to 10 mg/kg (7.5 (7.5)) 8 hourly Slow IV — As Required

Drug Interactions

Lincomycin (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcuronium (Cl)Atracurium (Besylate)BamifyllineClindamycinDistigmine (Br)ErythromycinKaolinRocuronium (Br) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Caps Store Below 30°C. Do not Freeze. Protect from Sunlight and Moisture.