Meclofenamic Acid

Meclofenamic Acid is anthranilic acid derivative similar to mefenamic acid, is an NSAID (non-steroidal anti-inflammatory drug). Meclofenamic Acid is given by mouth in musculoskeletal and joints disorders such as osteoarthritis and rheumatoid arthritis, in mild to moderate pain. The anti-inflammatory effects of these drugs may result from the peripheral inhibition of prostaglandin synthesis secondary to inhibition of the enzyme cyclooxygenase. Prostaglandins sensitize pain receptors and their inhibition is thought to be responsible for the analgesic effects of mefenamic acid . Unlike other NSAIDs, it appears to antagonize certain effects of existing prostaglandins through competition for prostaglandin binding sites.

Meclofenamic Acid is primarily indicated in conditions like Ankylosing spondylitis, Dysmenorrhea, Osteoarthritis, Rheumatoid arthritis.

Meclofenamic Acid is contraindicated in conditions like Hypersensitivity to any component of product.

Meclofenamic Acid produces potentially life-threatening effects which include Renal failure. which are responsible for the discontinuation of Meclofenamic Acid therapy. The signs and symptoms that are produced after the acute overdosage of Meclofenamic Acid include Oliguria, Agitation, Anuria. The symptomatic adverse reactions produced by Meclofenamic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Diarrhea, Constipation, Abdominal pain.

Meclofenamic acid should be used with caution in patients with intrinsic coagulation defects and those on anticoagulant therapy. It should be used with caution in patients with compromised cardiac function, hypertension other condition predisposing to fluid retention. It should be used with extra care in the presence of existing controlled infection. Perform periodic auditory function test during chronic therapy. Discontinue drug if skin reaction occurs.

Drug should not be given to Pregnant Mothers. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

100 mg (100 (100)) 6 hourly PO — Scraped Dose — The following is based on the little information available concerning overdosage with meclofenamate sodium and related compounds. After a massive overdose, CNS stimulation may be manifested by irrational behavior, marked agitation and generalized seizures. Following this phase, renal toxicity (falling urine output, rising creatinine, abnormal urinary cellular elements) may be noted with possible oliguria or anuria and azotemia. A 24 year-old male was anuric for approximately one week after ingesting an overdose of 6 to 7 grams of meclofenamate sodium. Spontaneous diuresis and recovery subsequently occurred. Management consists of emptying the stomach by emesis or lavage and instilling an ample dose of activated charcoal into the stomach. There is some evidence that charcoal will actively absorb meclofenamate sodium, but dialysis or hemoperfusion may be less effective because of plasma protein binding. The seizures should be controlled by an appropriate anticonvulsant regimen. Attention should be directed throughout, by careful monitoring, to the preservation of vital functions and fluid-electrolyte balance. Dialysis may be required to correct serious azotemia or electrolyte imbalance.

( ) — Not recommended in this age group

( ) — Not recommended in this age group

Meclofenamic Acid is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholCyclosporin APhenytoin (Na)Warfarin (Na)Meclofenamic Acid may enhance the anticoagulant effect of Warfarin. ModerateDelayedPatients receiving Warfarin should be instructed to not initiate Meclofenamic Acid without consulting his/her healthcare professional (nonacetylated salicylates might be safer alternatives). Acetaminophen is usually a good antipyretic and analgesic choice for patients taking Warfarin. Monitor for increased signs and symptoms of bleeding if Warfarin and Meclofenamic acid are used concomitantly. Zidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Cap Store in a well closed container. Protect from Sunlight.