Mephenytoin
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Mephenytoin is a hydantoin antiepileptic with actions similar to those of phenytoin, but it is more toxic. Because of its potential toxicity it is not one of the main drugs used in the treatment of epilepsy and is given only to patients unresponsive to other treatment.
Indications
Mephenytoin is primarily indicated in conditions like Epilepsy.
Contraindications
Mephenytoin is contraindicated in conditions like Diabetes mellitus,Cardiovascular disease,Hepatic impairment,Hypersensitivity to any component of product.
Side Effects
Mephenytoin produces potentially life-threatening effects which include Dyscrasia. which are responsible for the discontinuation of Mephenytoin therapy.The signs and symptoms that are produced after the acute overdosage of Mephenytoin include Coma, Seizures, Blurred vision, Drowsiness, Confusion, Ataxia, Dizziness, Slurred speech.The symptomatic adverse reactions produced by Mephenytoin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Irritability, Fever, Nervousness, Rashes, Pain, Itching, Burning, Bleeding, nervousness, Porphyria.
Warnings
Your doctor should check your progress at regular visits , especially during the first few months of treatment with this medicine. During this time the amount of medicine you are taking may have to be changed often to meet your individual needs. Do not start or stop taking any other medicine without your doctor's advice. Other medicines may affect the way this medicine works . This medicine will add to the effects of alcohol and other CNS depressants
High Risk Groups
Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
0.2 to 0.6 g (0.4 (0.4)) 24 hourly PO —
Child Dosage
50 to 0 mg (25 (25)) As recommended. Initially dose is maintained by 50 to 100 mg until dose is reached between 100 & 400 mg —
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Mephenytoin is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementClorazepate (K)Divalproex (Na)Divalproex (Na) may interact with Mephenytoin. It can either increase or decrease the effect of Mephenytoin. phenobarbital. HydrocortisonePhenobarbitonePhenobarbital may interact with Mephenytoin. It can either increase or decrease the effect of Mephenytoin. Valproic AcidValproic Acid may interact with Mephenytoin. It can either increase or decrease the effect of Mephenytoin. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Tablets Refrigeration and Freezing is not recommended. Protect from Sunlight, Moisture and Heat.
Available Brands in Pakistan
No brands are recorded for this generic.