Medicines/Generics/Mesalazine

Mesalazine

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Mesalazine is ingredient of sulfasalazine and Mesalazine is used in the treatment of ulcerative colitis. It can be given both by mouth or rectally.

Indications

Mesalazine is primarily indicated in conditions like Crohn's disease, Ulcerative colitis.

Contraindications

Mesalazine is contraindicated in conditions like Hypersensitivity.

Side Effects

The severe or irreversible adverse effects of Mesalazine, which give rise to further complications include Hepatitis, Bronchospasm, Nephrotic syndrome, Blood dyscrasias. Mesalazine produces potentially life-threatening effects which include Myocarditis, Pericarditis. which are responsible for the discontinuation of Mesalazine therapy. The symptomatic adverse reactions produced by Mesalazine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Alopecia, Diarrhea, Fever, Rashes, Hair loss, Chest pain, Leukopenia, Paresthesias, Abdominal discomfort.

Warnings

Avoid Mesalazine in patients with impaired renal function or salicylate or sulfite hypersensitivity. It should be used with caution in elderly. Avoid use in children under 2 years of age. If blood dyscrasia is suspected treatment should be stopped immediately and blood count should performed.

High Risk Groups

Drug should not be given to Pediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

800 mg (800 (800)) 8 hourly PO —

Child Dosage

10 mg/kg (10 (10)) 8 hourly Maintanance ,To maximum of 500mg — 15 to 0 mg/kg (7.5 (7.5)) 8 hourly For acute attacks (maximum 1g) —

Neonatal Dosage

( ) — Not recommended in this age group

Drug Interactions

No data regarding the interactions of Mesalazine was found.

Storage

Tab, Supposotories, Enema Store in a well closed container, . Protect from Sunlight.