Mesna
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Mesna is used to prevent bleeding in the bladder (hemorrhagic cystitis ) during chemotherapy with ifosfamide ( Ifex ).
Mesna will not prevent other side effects caused by ifosfamide.
Mesna may also be used for purposes not listed in this medication guide.
Indications
Mesna is used to prevent bleeding in the bladder (hemorrhagic cystitis ) during chemotherapy with ifosfamide ( Ifex ).
Mesna will not prevent other side effects caused by ifosfamide.
Mesna may also be used for purposes not listed in this medication guide.
Contraindications
You should not use mesna if you are allergic to mesna, edetate sodium, sodium hydroxide, or benzyl alcohol .
Tell your doctor if you are allergic to any medicine.
Although mesna is not expected to harm an unborn baby, ifosfamide can harm an unborn baby if the mother or the father is using this medicine.
If you are a woman, you may need to have a negative pregnancy test before starting this treatment with ifosfamide. Use effective birth control to prevent pregnancy while you are using ifosfamide and for at least 6 months after your last dose. If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose of ifosfamide. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ifosfamide.
Do not breast-feed while using mesna or ifosfamide, and for at least 1 week after your last dose.
Mesna injection contains an ingredient that can cause serious side effects or death in premature or low-birthweight babies. Mesna tablets do not contain this ingredient. Mesna injection should not be given to a premature or low birth weight infant.
Side Effects
Get emergency medical help if you have signs of an allergic reaction or severe skin reaction:
fever , nausea , vomiting , joint or muscle pain ; hives, rash or redness, skin pain or swelling, blisters or peeling; feeling light-headed, trouble breathing; racing heartbeats; or mouth sores, or swelling in your face or throat.
Mesna may cause serious side effects. Call your doctor at once if you have:
chest pain, trouble breathing; easy bruising or bleeding (nosebleeds, bleeding gums); low red blood cells (anemia) --pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or low potassium level --leg cramps, constipation , irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.
Common side effects of mesna may include:
nausea, vomiting, stomach pain, loss of appetite; diarrhea , constipation; weakness, tiredness, drowsiness ; headache ; hair loss ; or fever, flu-like symptoms.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Get emergency medical help if you have signs of a serious reaction: fever, nausea, vomiting, racing heartbeats, hives, rash or redness, skin pain or swelling, blisters or peeling, joint or muscle pain, feeling light-headed, trouble breathing, mouth sores, or swelling in your face or throat.
High Risk Groups
Get emergency medical help if you have signs of a serious reaction: fever, nausea, vomiting, racing heartbeats, hives, rash or redness, skin pain or swelling, blisters or peeling, joint or muscle pain, feeling light-headed, trouble breathing, mouth sores, or swelling in your face or throat.
Adult Dosage
1.625 to 1.82 g/sq.metre (1.7 (1.7225)) As recommended. IV Inf — 100-112% by weight of Ifosamide, As Required
1.625 to 1.82 g/sq.metre (1.7 (1.7225)) 6 hourly PO — 100-112% by weight of ifosamide
Child Dosage
240 to 360 mg/sq.meter (300 (300)) 8 hourly Intra Venous — 20%w/w of Ifosfamide Dose
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Other drugs may affect mesna, including prescription and over-the-counter medicines, vitamins , and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
Tab, Inj Store at room temperature, Below 30°C. Protect from Sunlight.
Available Brands in Pakistan
No active brands are currently recorded for this generic.
4 records are present but flagged "Unverified / Legacy" and excluded.
