Methotrimeprazine (Maleate)

Methotrimeprazine (Maleate) is antipsychotic with actions, uses and adverse effects similar to Chlorpromazine.it also possess some analgesic and sedating properties perticularly useful in terminal care. Chemically Methotrimeprazine (Maleate) is 2-methoxy-N, N, ß-trimethyl-10H-phenothiazine-10-propanamine. Methotrimeprazine (Maleate) is available in both oral and parentral forms. Methotrimeprazine (Maleate) is also used to treat schizophrenia and agitated depression.

Methotrimeprazine (Maleate) is primarily indicated in conditions like Anxiety, Moderate to severe pain, Psychosis, Schizophrenia.

Methotrimeprazine (Maleate) is contraindicated in conditions like Bone marrow depression, Coma, Heart disease, Close-angle glaucoma.

The severe or irreversible adverse effects of Methotrimeprazine (Maleate), which give rise to further complications include Tardive dyskinesia, Paralytic ileus, Seizures, Intrahepatic cholestasis, Lens opacities, Maculopathy, Respiratory distress. Methotrimeprazine (Maleate) produces potentially life-threatening effects which include Agranulocytosis, Neuroleptic Malignant Syndrome. which are responsible for the discontinuation of Methotrimeprazine (Maleate) therapy. The signs and symptoms that are produced after the acute overdosage of Methotrimeprazine (Maleate) include Hypotension, Tachycardia, ECG alterations, Drowsiness, Hypothermia, Ventricular arrhythmias, Severe extrapyramidal dyskinesia, Loss of consciousness. The symptomatic adverse reactions produced by Methotrimeprazine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Sedation, Photosensitivity, Parkinsonism, Hypotension, Weight gain, Asthenia, Contact dermatitis, Erythematous rash, Head stroke.

Methotrimeprazine should be used in low initial dose. Monitor pulse and blood pressure until dosage requirements and responses are stabilized in elderly and debilitated patients.

Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.178 to 0.357 mg/kg (0.27 (0.2675)) 6 hourly IM — - 0.357 to 2.857 mg/kg (1.6 (1.607)) 24 hourly SC — - 0.476 to 14.285 mg/kg (7.4 (7.3805)) 24 hourly PO — -

12.5 to 0 mg (6.2 (6.25)) As recommended. Individed doses. —

( ) — Not recommended in this age group

Methotrimeprazine (Maleate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAdrenalineAlcoholBuspirone (HCl)Cimetidine (HCl)Citalopram (HBr)CocainedeferoxamineDisulfiramDronabinolIt may Increase the levels/effect of alcohol.PiperazineVORICONAZOLEdditive QTc prolongation may occur. Consider alternate therapy or monitor for QTc prolongation These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

IV Inj, IV Inf, IM Inj, SC Inf Store at room temperature, Between 15°C-30°C. Protect from Sunlight.