Methotrimeprazine(HCl)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Methotrimeprazine(HCl) is phenothiazine with actions and pharmacological properties similar to that of both chlorpromazine and promethazine. Methotrimeprazine(HCl) is used intramuscularly (IM), in the treatment of various psychoses including schizophrenia, as an adjunct to analgesics in the management of severe terminal pain. Methotrimeprazine (HCl) is also used as a premedicant and is given prior to surgical procedures.
Indications
Methotrimeprazine(HCl) is primarily indicated in conditions like Anxiety, Moderate to severe pain, Psychosis, Schizophrenia.
Contraindications
Methotrimeprazine(HCl) is contraindicated in conditions like Bone marrow depression, Coma, Heart disease, Close-angle glaucoma.
Side Effects
The severe or irreversible adverse effects of Methotrimeprazine(HCl), which give rise to further complications include Tardive dyskinesia, Paralytic ileus, Seizures, Lens opacities, Maculopathy, Respiratory distress. Methotrimeprazine(HCl) produces potentially life-threatening effects which include Agranulocytosis, Malignant neoplastic syndrome. which are responsible for the discontinuation of Methotrimeprazine(HCl) therapy. The signs and symptoms that are produced after the acute overdosage of Methotrimeprazine(HCl) include Hypotension, Tachycardia, ECG alterations, Drowsiness, Hypothermia, Ventricular arrhythmias, Severe extrapyramidal dyskinesia, Loss of consciousness. The symptomatic adverse reactions produced by Methotrimeprazine(HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dry mouth, Sedation, Photosensitivity, Parkinsonism, Hypotension, Weight gain, Asthenia, Contact dermatitis, Erythematous rash.
Warnings
Methotrimeprazine should be used in low initial dose. Monitor pulse and blood pressure until dosage requirements and responses are stabilized in elderly and debilitated patients.
High Risk Groups
Drug should not be given to Pregnant Mothers, Cardiac / Hypertensive Patients, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
50 to 75 mg/day (62 (62.5)) As recommended. PO — For severe conditions: should be given in 2-3 divided doses.Increase the dosage until the optimum level has been reached.
6 to 25 mg/day (16 (15.5)) As recommended. PO — For minor conditions: should be given in 3 divided doses.Increase the dosage until the optimum level has been reached.
Child Dosage
100 to 0 mg (50 (50)) As recommended. IV or S/C —
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
No data regarding the interactions of Methotrimeprazine(HCl) was found.
Storage
Store in a well closed container, . Protect from Sunlight.
Available Brands in Pakistan
No brands are recorded for this generic.