Methylene Blue

Methylene blue is an oxidation-reduction agent used to treat methemoglobinemia , a condition where hemoglobin is oxidized, impairing its ability to carry oxygen. Methylene blue works by reducing the oxidized hemoglobin, converting it back to hemoglobin so that it can carry oxygen properly again. Methemoglobinemia can lead to symptoms like cyanosis, fatigue, and shortness of breath. When used for methemoglobinemia, methylene blue is given as an injection by your healthcare provider in a hospital or clinic. Methylene blue  FDA approval was granted on April 8, 2016, for treating methemoglobinemia under the brand name Provayblue. This medicine does not reverse methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, and it may induce or worsen hemolysis in these patients. Methylene blue is also called methylthioninium chloride . Methylene blue has also been used as a diagnostic dye, for malaria, shock, cystitis, urethritis, cyanide and carbon monoxide poisoning, and ifosfamide-induced encephalopathy off-label .

Methylene blue is an oxidation-reduction agent used to treat methemoglobinemia , a condition where hemoglobin is oxidized, impairing its ability to carry oxygen. Methylene blue works by reducing the oxidized hemoglobin, converting it back to hemoglobin so that it can carry oxygen properly again. Methemoglobinemia can lead to symptoms like cyanosis, fatigue, and shortness of breath. When used for methemoglobinemia, methylene blue is given as an injection by your healthcare provider in a hospital or clinic. Methylene blue  FDA approval was granted on April 8, 2016, for treating methemoglobinemia under the brand name Provayblue. This medicine does not reverse methemoglobinemia in patients with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, and it may induce or worsen hemolysis in these patients. Methylene blue is also called methylthioninium chloride . Methylene blue has also been used as a diagnostic dye, for malaria, shock, cystitis, urethritis, cyanide and carbon monoxide poisoning, and ifosfamide-induced encephalopathy off-label .

You should not be treated with methylene blue if you are allergic to it, or if you have: a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency. Many drugs can interact with methylene blue. Tell your doctor about all your current medicines and any you recently stopped using, especially: alfentanil, fentanyl; buspirone; digoxin, digitalis; dihydroergotamine, ergotamine; phenytoin; pimozide; quinidine; warfarin (Coumadin, Jantoven); an MAO inhibitor - isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine , and others; an "SSRI" antidepressant - citalopram , escitalopram , fluoxetine, paroxetine, sertraline, Prozac, Paxil, Zoloft, and others; an "SNRI" antidepressant - desvenlafaxine , duloxetine , levomilnacipran , milnacipran , venlafaxine , Effexor, Cymbalta, Pristiq, and others; other antidepressants - bupropion, clomipramine , mirtazapine ; or medicine to prevent organ transplant rejection - cyclosporine, sirolimus, tacrolimus. To make sure methylene blue is safe for you, tell your doctor if you have: liver disease ; or kidney disease. Using methylene blue during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant. Do not breast-feed within 8 days after you received methylene blue. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers right away if you have: confusion or weakness; pale or yellowed skin; dark colored urine; fever; or high levels of serotonin in the body - agitation, hallucinations, fever, fast heart rate , overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting. Common side effects of methylene blue may include: pain in your arms or legs; blue or green urine; altered sense of taste; headache, dizziness; sweating, skin discoloration; nausea; or feeling hot. This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

You should not be treated with methylene blue if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency or a severe hypersensitivity to methylene blue. Many drugs can interact with methylene blue. Tell your doctor about all your current medicines and any you recently stopped using, especially an antidepressant.

You should not be treated with methylene blue if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency or a severe hypersensitivity to methylene blue. Many drugs can interact with methylene blue. Tell your doctor about all your current medicines and any you recently stopped using, especially an antidepressant.

0.928 to 1.857 mg/kg (1.4 (1.3925)) 8 hourly PO — -

2 mg/kg (2 (2)) 8 hourly Oral —

3 mg/kg (3 (3)) 8 hourly Oral — -

Many drugs can interact with methylene blue, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products . Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you have recently used before your treatment with methylene blue.

Inj Store Between 15°C-30°C. Protect from Sunlight, Moisture and Heat.