Methylergometrine (Maleate)

Methylergometrine (Maleate) also known as methylergonovine. It is a medication of the ergoline and lysergamide groups which is used as an oxytocic in obstetrics and in the treatment of migraine. It reportedly produces psychedelic effects similar to those of lysergic acid diethylamide (LSD) at high doses.

Methylergometrine (Maleate) is primarily indicated in conditions like Postabortal hemorrhage, Postpartum hemorrhage, Uterine bleeding, Uterine subinvolution, and can also be given in adjunctive therapy as an alternative drug of choice in Uterine atony.

Methylergometrine (Maleate) is contraindicated in conditions like Abortion, Heart disease, Labor augmentation, Peripheral obliterative vascular disease, Arteriovenous shunt, Pregnancy-induced hypertension.

The severe or irreversible adverse effects of Methylergometrine (Maleate), which give rise to further complications include Vascular complications, Ischemia, Gangrene, Cold extremities. Methylergometrine (Maleate) produces potentially life-threatening effects which include Coma, Seizures, Nausea, Vomiting, Hypertension, Hypotension, Diarrhea. which are responsible for the discontinuation of Methylergometrine (Maleate) therapy. The signs and symptoms that are produced after the acute overdosage of Methylergometrine (Maleate) include Nausea, Vomiting, Seizures, Angina, Confusion, Unconsciousness, Palpitations, Dizziness, Hypertension, Gangrene, Dyspnea, Vasoconstriction of the extremities. The symptomatic adverse reactions produced by Methylergometrine (Maleate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Palpitation, Tinnitus, Abdominal pain, Vertigo, Chest pain, Angina, Shortening of breath.

Methylergometrine should not be used for the induction of labor or during the first stage of labor. Its use should be avoided in patients with eclampsia. IV injection should be given slowly. The drug should be administered under careful obstetric supervision to shorten the third stage of the labor after the delivery of the anterior shoulder of the fetus.

Drug should not be given to Pediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

0.2 mg (0.2 (0.2)) 4.8 hourly IM,Slow IV —

( ) — Not recommended in this age group

( ) — Not recommended in this age group

Methylergometrine (Maleate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementHalothaneVORICONAZOLEVoriconazole may increase the serum concentration of methylergonovine by decreasing its metabolism. Concomitant therapy is contraindicated. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Tab, IV Inj, IM Inj Store Below 25°C. Protect from Sunlight.