Methyprylone
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Chemically Methyprylone is 3, 3-diethyl-5-methyl-2, 4-piperidinedione. Methyprylone is oral hypnotic and used in the management of insomnia of varied etiology.
Indications
Methyprylone is primarily indicated in conditions like Insomnia.
Contraindications
Methyprylone is contraindicated in conditions like Alcohol dependence, Depression, Porphyria, Sleep apnea syndrome.
Side Effects
The severe or irreversible adverse effects of Methyprylone, which give rise to further complications include Hallucinations, Anxiety, Polyuria, Seizures, Dependence, Hyperreflexia.Methyprylone produces potentially life-threatening effects which include Pulmonary edema, Coma, Respiratory depression, Hypotension. which are responsible for the discontinuation of Methyprylone therapy.The signs and symptoms that are produced after the acute overdosage of Methyprylone include Coma, Hyperthermia, Respiratory depression, Pupillary changes, Hypothermia, Nystagmus, Dysarthria. The symptomatic adverse reactions produced by Methyprylone are more or less tolerable and if they become severe, they can be treated symptomatically, these include GI disturbance, CNS disturbances.
Warnings
Patient should observe caution while driving or performing other task requiring alertness because it may produce dizziness. Total daily intake should not exceed to 400 mg. Methyprylone should be used with caution in patients with kidney and liver disease. Perform periodic blood counts if use over prolonged period. Patients should be warned against the concomitant use of Methyprylone and alcohol or other CNS depressants. Habituation and physical dependence have been reported to occur when excessive doses are taken over an extended period of time.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
0.714 to 1.904 mg/kg (1.3 (1.309)) 8 hourly PO — -
Child Dosage
( ) — Not recommended in this age group
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
No data regarding the interactions of Methyprylone was found.
Storage
Store at room temperature, .
Available Brands in Pakistan
No brands are recorded for this generic.