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Medicines/Generics/Neostigmine

Neostigmine

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Neostigmine is used to reverse the effects of anesthesia medications used during surgery . Neostigmine may also be used for purposes not listed in this medication guide.
Indications
Neostigmine is used to reverse the effects of anesthesia medications used during surgery . Neostigmine may also be used for purposes not listed in this medication guide.
Contraindications
You should not be treated with neostigmine if you are allergic to it, or if you have: a bladder obstruction or other urination problems; a blockage in your digestive tract (stomach or intestines); or a serious disorder called peritonitis (inflammation of the membrane lining the organs inside your abdomen). Tell your doctor if you have ever had: coronary artery disease (clogged arteries); a heart rhythm disorder; or myasthenia gravis . Tell your doctor if you are pregnant or breastfeeding.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers right away if you have muscle weakness as you wake up from surgery. Common side effects of neostigmine may include: nausea , vomiting ; or slow heartbeats. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
You should not be treated with neostigmine if you have a bladder or bowel obstruction , or a serious disorder called peritonitis (inflammation of the membrane lining the organs inside your abdomen).
High Risk Groups
You should not be treated with neostigmine if you have a bladder or bowel obstruction , or a serious disorder called peritonitis (inflammation of the membrane lining the organs inside your abdomen).
Adult Dosage
0.02 mg/ kg (0.02 (0.02)) As recommended. IM — For diagnosis of myasthenia gravis 0.5 to 2.5 mg (1.5 (1.5)) As recommended. IV, IM, SC — Additional doses depend upon the patient response. Max. 10mg/day 15 mg (15 (15)) 4 hourly PO — Max. 375mg/day
Child Dosage
200 to 0 mg/kg (100 (100)) 6 hourly Oral — For Myasthenia grains. 50 to 0 ug/kg (25 (25)) As recommended. Intra Venous — To severe neuromuscular blockade.
Neonatal Dosage
0.5 to 1 mg/kg (0.75 (0.75)) 6 hourly Oral — For all ages 50 ug/kg (50 (50)) As recommended. Intravenous — As required
Drug Interactions
Other drugs may affect neostigmine, including prescription and over-the-counter medicines, vitamins , and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C.