Netilmicin (Sulphate)

Netilmicin is a semisynthetic aminoglycoside antibiotic derived from Sisomicin, having a range of antibacterial activity similar to that of gentamicin and tobramycin. The Sulphate salt of netilmicin, administered intramuscularly and intravenously in the treatment of wide variety of infections caused by susceptible gram-negative organism. Netilmicin (Sulphate) is active alone but also exhibit synergism with ß lactam antibiotic. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Netilmicin (Sulphate) is important to take the drug for the full time period as prescribed. Discontinuation of the therapy may result in ineffective treatment.

Netilmicin (Sulphate) is primarily indicated in conditions like Advanced breast cancer in postmenopausal women, Bacterial infections, Gonorrhea, Heart failure, Joint infections, Septicemia, Serious gram -ive infections resistant to gentamicin, Supraventricular arrhythmias (particularly atrial fibrillation), Surgical infections, Urinary tract infection, UTI.

Netilmicin (Sulphate)

The severe or irreversible adverse effects of Netilmicin (Sulphate), which give rise to further complications include Nephrotoxicity, Ototoxicity. Netilmicin (Sulphate) produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Netilmicin (Sulphate) therapy. The symptomatic adverse reactions produced by Netilmicin (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Maculopapular rash, Urticaria, Pain, Phlebitis, Elevated hepatic transaminases.

Netilmicin should be used with caution in patients with history of kidney diseases, vertigo, hearing loss, myasthenia gravis, parkinsonism. It should be used with caution in patients who are sensitive to aminoglycosides. Keep patients well hydrated to prevent chemical irritation or nephrotoxic reactions. Take appropriate measures in case of secondary infections.

Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

4 to 6 mg/kg (5 (5)) As recommended. IV,IM, PO — As a single dose. Dose may be increased upto 6.5 mg/kg/day in 2 divided doses, depending on the severity and location of infection.

2.142 mg/kg (2.1 (2.142)) 12 hourly Intra Muscular — For 3 to 5 minutes 2.142 mg/kg (2.1 (2.142)) 12 hourly Intra Venous — For 3 to 5 minutes

2.142 mg/kg (2.1 (2.142)) 12 hourly Intra Muscular — For 3 to 5 minutes 2.142 mg/kg (2.1 (2.142)) 12 hourly Intra Venous — For 3 to 5 minutes

Netilmicin (Sulphate) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCephradineCisplatinGentamicinRespiratory paralysis and renal dysfunction risk is increased if this combination is used.MajorThis combination should be avoided.Polymyxin B (Sulphate)Vancomycin (HCl) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj Store Between 20°C-25°C. Do not Freeze.