Nicorandil

Nicorandil is a derivative of nicotinamide, acts as a vasodilator and facilitates the opening of potassium-channels. It produces vasodilation of arterioles and large coronary arteries, while the nitrate component produces venous vasodilatation. Nicorandil is used in the management of angina pectoris.

Nicorandil is primarily indicated in conditions like Acute heart failure, Stable angina pectoris, Unstable angina.

Nicorandil is contraindicated in conditions like Cardiogenic shock, Hypotension, Left ventricular failure, Additional vascular conditions.

The severe or irreversible adverse effects of Nicorandil, which give rise to further complications include Hepatic function abnormalities. The signs and symptoms that are produced after the acute overdosage of Nicorandil include Hypotension. The symptomatic adverse reactions produced by Nicorandil are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Dizziness, Headache, Fatigue, Nausea, Vomiting, Myalgia, Palpitation, Skin rash, Malaise, Hypotension, Flushing, Angioedema, Weakness.

It should be used with caution in patients with hypovolemia, low systolic blood pressure or acute pulmonary edema.

Drug should not be given to Paediatrics, Pregnant Mothers, Cardiac / Hypertensive Patients, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

No adult dosage information is recorded for this medicine yet.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Nicorandil is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementHydralazine (HCl)Concurrent use can cause a drop in blood pressure, therefore you should tel your doctor know if you feel dizzy during concurrent use of these drugs. MinoxidilConcurrent use can cause a drop in blood pressure, therefore you should tel your doctor know if you feel dizzy during concurrent use of these drugs. Prednisolone and PrednisoneThere may be an increased risk of ulceration or bleeding in the stomach or intestines if corticosteroids such as prednisolone are taken in combination with this Nicorandil.SildenafilConcurrent use can cause a dangerous drop in blood pressure, therefore this combination should be avoided.TadalafilConcurrent use can cause a dangerous drop in blood pressure, therefore this combination should be avoided. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Tab Store Below 25°C. Protect from Moisture.