Nicotinic Acid

Nicotinic Acid is a pyridine-3-carboxylic acid. It has identical properties as vitamin. Nicotinic Acid is also called as a vitamin B7. In 1867 nicotinic acid was synthesized by the oxidation of nicotine with nitric acid. Nicotinic Acid is involved in tissue respiration, energy production for the body and fat metabolism. It has relaxant effect on blood vessels. Nicotinic Acid is used to treat reduced peripheral circulation. It lowers the blood cholesterol and fat levels. Deficiency causes pellagra, with dermatitis, diarrhea, and dementia. The sources are poultry, meats, fish, potatoes, legumes and some green leafy vegetables.

Nicotinic Acid is primarily indicated in conditions like Hypercholesterolemia, Hyperlipidemia, Hypertriglyceridemia, Pellagra, and can also be given in adjunctive therapy as an alternative drug of choice in Acne.

Nicotinic Acid is contraindicated in conditions like Diabetes mellitus, Gout, Peptic ulcer.

The severe or irreversible adverse effects of Nicotinic Acid, which give rise to further complications include Urticaria, Jaundice, Hyperuricemia, Cramps, Myalgia, Blurred vision, Acanthosis nigricans, Ichthyosis, Toxic amblyopia, Atrial arrhythmias, Elevated serum aspartate transaminase, Elevated serum creatine kinase. Nicotinic Acid produces potentially life-threatening effects which include Hepatitis, Hepatic failure, Hepatic fibrosis. which are responsible for the discontinuation of Nicotinic Acid therapy. The signs and symptoms that are produced after the acute overdosage of Nicotinic Acid include Flushing, Headache, Pruritus. The symptomatic adverse reactions produced by Nicotinic Acid are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Diarrhea, Gastric irritation, Hypotension, Flushing, Faintness, Bloating, Headache, Abdominal pain, Pruritus, Rash.

Nicotinic acid should be used with caution in patient predisposed to gout because of the elevation of uric acid level. Closely observed patient with gallbladder disease, history of jaundice, liver disease, peptic ulcer, arterial bleeding, glaucoma & diabetic patient for decreased glucose tolerance. Some products contain tartrazine, which causes allergic reaction (including bronchial asthma) in susceptible individuals specially who have aspirin sensitivity. Should be given with caution in gouts diabetes mellitus.

Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

100 to 200 mg (150 (150)) 8 hourly PO —

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Nicotinic Acid is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAtorvastatinIncreased risk of myopathy when statin (e.g Atorvastatin) given with nicotinic acid (applies to lipid regulating doses of nicotinic acid.Cerivastatin SodiumCerivastatin sodium causes additive toxicity with Nicotinic AcidColestipol (HCl)FluvastatinGlibornurideGliquidoneTechnetium Tc-99m DisofeninChronic, high-dose nicotinic acid therapy may result in poor extraction and elimination of the radiopharmaceutical, mimicking intrinsic hepatocellular disease.Technetium Tc-99m lidofeninNonvisualization of gallbladder may occur due to erthromycin-induced hepatotoxicity. These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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