Medicines/Generics/Nimesulide

Nimesulide

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Nimesulide is NSAID ( non steroidal anti-inflammatory drug) reported to be selective inhibitor of cyclo-oxygenase-2 (COX-2). It has been given by mouth or rectally for inflammatory condition, fever and pain.

Indications

Nimesulide is primarily indicated in conditions like Bursitis, Fever, Gynecological infections, Inflammation, Osteoarthritis, Pain, Rheumatoid arthritis, Tendinitis, Thrombophlebitis, Trauma, and can also be given in adjunctive therapy as an alternative drug of choice in Ent infections.

Contraindications

Nimesulide is contraindicated in conditions like GI ulceration, GI hemorrhage.

Side Effects

The severe or irreversible adverse effects of Nimesulide, which give rise to further complications include Stevens Johnson syndrome, Lyell's syndrome, hepatoxicity. Nimesulide produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Nimesulide therapy. The signs and symptoms that are produced after the acute overdosage of Nimesulide include Hypotension, Hypothermia. The symptomatic adverse reactions produced by Nimesulide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Drowsiness, Nausea, Pain, Vertigo, Thrombocytopenia, Melena, Diaphoresis, Erythema, Gastralgia, Flushing, Facial edema, Sleep disorder, Vertigo, Purpuric skin lesions.

Warnings

Nimesulide must be used with care among patients with a history of bleeding, with illnesses of the upper gastrointestinal tract and to subjects undergoing treatment with anticoagulants or drugs that inhibit platelet aggregation. The patients must be under direct medical supervision while taking substances with limited gastric tolerance at the same time. Since the drug is eliminated mainly through the kidneys, patient with the renal insufficiency must have a lower dosage depending on the glomerular filtration rate. The product must not be administered to the patient with severe renal insufficiency. The product can cause water retention, therefore it must not be administered to the patient with reduced cardiac function. Patients whose activity require alertness must take the product with care in case they notice drowsiness or vertigo during therapy . Cases of visual disturbances when using other non-steroidal anti-inflammatory drugs have been reported, If eye problems appear, the treatment must be interrupted and an eye examination must be performed.

High Risk Groups

Drug should not be given to Pregnant Mothers, and Geriatrics.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

0 to 100 mg (50 (50)) 12 hourly PO — Increase upto 200mg bid. 3 to 0 % (1.5 (1.5)) As recommended. topical — Increase upto 200mg bid.

Child Dosage

( ) — Not recommended in this age group

Neonatal Dosage

( ) — Not recommended in this age group

Drug Interactions

No data regarding the interactions of Nimesulide was found.

Storage

No storage information is recorded for this medicine yet.

Available Brands in Pakistan

50 active brands listed alphabetically.

Nimesulide

Available Brands in Pakistan

AMSOLIDE

ANALID

ARTILIDE

BLUNID

COX-2

COXOBID

ENIM

EXILIDE

FENSULID

FRENDCOGEN

GEOSLIDE

GRAVX

LEDOREN

LEMIDE

LIDE

MARICOX

MELIDE

MESULID

MODACT-IR

MUSIDE

NARCOGEN

NELSID

NEMSIS

NEOLIDE

NICOX

NIMARAN

NIMASE

NIMBEX-100

NIMCID

NIMEROL

NIMESOTA

NIMEX

NIMOLIVE

NIMS

NIMSIDE

NIMSULID

NIMVISTA

NISE

NOACH

NULIDE

ORINA

OSTEOSOFT

PAIN-AID

PENSULIDE

RAKALIDE

RHEUSLIDE

SLIDE

SULIDE-100

UNIX

WULID