Nitrazepam
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Nitrazepam is a 1,4-benzodiazipine. A substituent in the 7th position such as halogen or a nitro group is required for its sedative-hypnotic activity. It has depressant action on CNS. Used in the treatment of insomnia. Nitrazepam is not available in any combination preparations. Nitrazepam is administered orally. May cause dependence even in therapeutic dosage.
Indications
Nitrazepam is primarily indicated in conditions like Warts, Insomnia.
Contraindications
Nitrazepam
Side Effects
The severe or irreversible adverse effects of Nitrazepam, which give rise to further complications include Aggression, Anxiety. Nitrazepam produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Nitrazepam therapy. The signs and symptoms that are produced after the acute overdosage of Nitrazepam include Drowsiness, Ataxia, Sedation, Dysarthria. symptomatic adverse reactions produced by Nitrazepam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Constipation, Blurred vision, Vertigo, Hypotension, Loss of libido, Slurred speech, Respiratory depression.
Warnings
Perform periodic blood counts and liver function tests during long term therapy. Nitrazepam should be used with caution in patients if increased salivation cause respiratory difficulty, because it may produce an increase in salivation. Give least amount of drug to patients in whom depression accompanies anxiety and suicidal tendencies may be present. It should be used with caution (if it contains tartrazine) in patients with aspirin hypersensitivity because it may cause allergic reaction (including bronchial asthma). It should be used with caution in patients with porphyria.
High Risk Groups
Drug should not be given to Pregnant Mothers, and Geriatrics. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
5 to 10 mg (7.5 (7.5)) As recommended. PO — At bed time
Child Dosage
0.25 mg/kg (0.25 (0.25)) 12 hourly Oral — -
Neonatal Dosage
0.25 mg/kg (0.25 (0.25)) 12 hourly Oral — -
Drug Interactions
No data regarding the interactions of Nitrazepam was found.
Storage
Tab, Susp Store at room temperature, Below 30°C. Protect from Sunlight.
Available Brands in Pakistan
1 active brand listed alphabetically.
MOGADON
ActiveROCHE PAKISTAN LTD.
DML: MOGADON
Tabs