Nitrendipine
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
A calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.
Indications
Nitrendipine is primarily indicated in conditions like Mild to moderate hypertension.
Contraindications
Nitrendipine is contraindicated in conditions like Hypotension,Aortic stenosis,Hypersensitivity to any component of product.
Side Effects
The signs and symptoms that are produced after the acute overdosage of Nitrendipine include Bradycardia, Confusion, Hyperglycemia, myocardial depression.The symptomatic adverse reactions produced by Nitrendipine are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Fatigue, Nausea, Palpitation, Flushing, Edema, Gingival hyperplasia, vasodialation.
Warnings
Reduce dosage in elderly; use with caution in patients with liver insufficiency, digital ischemia, nonobstructive hypertrophic cardiomyopathy, Duchenne muscular dystrophy, or in combination with beta-blocking agents. Blood pressure lowering must be done at a rate appropriate for the patient's clinical condition.
High Risk Groups
If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
20 mg/day (20 (20)) As recommended. PO —
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Nitrendipine is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAminoglutethimideAminoglutethimide may decrease the levels/effects of nitrendipine.CarbamazepineCarbamazepine may decrease the levels/effects of nitrendipine.ClarithromycinMay increase the levels/effects of nitrendipineDiclofenac (K)May increase the levels/effects of nitrendipineDiclofenac (Na)May increase the levels/effects of nitrendipine.Diclofenac DiethylammoniumMay increase the levels/effects of nitrendipine.Diclofenac Free AcidMay increase the levels/effects of nitrendipineDigoxinAt nitrendipine doses exceeding 20 mg/day, increased digoxin levels and toxicity can occur. ErythromycinMay increase the levels/effects of nitrendipine.Nefazodone (HCl)May increase the levels/effects of nitrendipine.NevirapineNevirapine may decrease the levels/effects of nitrendipine.NicardipineMay increase the levels/effects of nitrendipine.Phenytoin (Na)Phenytoin (Na) may decrease the levels/effects of nitrendipine.QuinidineMay increase the levels/effects of nitrendipine.SildenafilBlood pressure-lowering effects may be additive.TadalafilBlood pressure-lowering effects may be additiveVerapamil (HCl)May increase the levels/effects of nitrendipine.VORICONAZOLEVoriconazole may increase the serum concentration of nitrendipine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
No storage information is recorded for this medicine yet.
Available Brands in Pakistan
No brands are recorded for this generic.