Oxymorphone

Oxymorphone is used to manage pain severe enough to require an opioid pain medicine when other pain medicines do not treat pain well enough, or are not tolerated. It is a strong prescription oral pain medicine that contains an opioid (narcotic) Oxymorphone tablets are used to manage short-term (acute) pain. Oxymorphone extended-release tablets are used to manage severe and persistent pain that requires an extended treatment period with a daily opioid pain medicine. Oxymorphone can put you at risk for overdose and death . Even if you take your dose correctly as prescribed, you are at risk for opioid addiction, abuse, and misuse that can lead to death. The FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for opioid analgesics to balance benefits against risks of addiction and misuse. Prescribers must complete REMS-compliant education, counsel patients on safe use and disposal, ensure patients read Medication Guides, and consider patient-prescriber agreements to enhance safety. Oxymorphone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. It provides analgesia with no ceiling effect , meaning doses are limited only by adverse effects like respiratory and CNS depression. Its precise analgesic mechanism is unknown, but CNS opioid receptors throughout the brain and spinal cord are believed to be involved. Oxymorphone first gained FDA approval on April 2, 1959 and is a Schedule II controlled substance. Oxymorphone is only available as a generic as the brand names Opana, Opana ER and Numorphan have been discontinued.

Oxymorphone is used to manage pain severe enough to require an opioid pain medicine when other pain medicines do not treat pain well enough, or are not tolerated. It is a strong prescription oral pain medicine that contains an opioid (narcotic) Oxymorphone tablets are used to manage short-term (acute) pain. Oxymorphone extended-release tablets are used to manage severe and persistent pain that requires an extended treatment period with a daily opioid pain medicine. Oxymorphone can put you at risk for overdose and death . Even if you take your dose correctly as prescribed, you are at risk for opioid addiction, abuse, and misuse that can lead to death. The FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for opioid analgesics to balance benefits against risks of addiction and misuse. Prescribers must complete REMS-compliant education, counsel patients on safe use and disposal, ensure patients read Medication Guides, and consider patient-prescriber agreements to enhance safety. Oxymorphone is a full opioid agonist and is relatively selective for the mu-opioid receptor, although it can bind to other opioid receptors at higher doses. It provides analgesia with no ceiling effect , meaning doses are limited only by adverse effects like respiratory and CNS depression. Its precise analgesic mechanism is unknown, but CNS opioid receptors throughout the brain and spinal cord are believed to be involved. Oxymorphone first gained FDA approval on April 2, 1959 and is a Schedule II controlled substance. Oxymorphone is only available as a generic as the brand names Opana, Opana ER and Numorphan have been discontinued.

Do not take oxymorphone if you have: Severe asthma Trouble breathing or other lung problems A bowel blockage or a narrowing of the stomach or intestines An allergy to oxymorphone or any of the ingredients in your oxymorphone preparations. Before taking oxymorphone, tell your healthcare provider if you have a history of: Head injury, seizures Liver, kidney, thyroid problems Problems urinating Pancreas or gallbladder problems Abuse of street or prescription drugs, alcohol addiction, opioid overdose, or mental health problems. Tell your healthcare provider if you are: Noticing your pain is getting worse. If your pain gets worse after you take oxymorphone, do not take more of oxymorphone without first talking to your healthcare provider. Talk to your healthcare provider if the pain that you have increases, if you feel more sensitive to pain, or if you have new pain after taking oxymorphone. Pregnant or planning to become pregnant. Using oxymorphone for an extended period of time during pregnancy can cause withdrawal symptoms in your newborn baby that could be life-threatening if not recognized and treated. Breastfeeding. oxymorphone passes into breast milk and may harm your baby. Carefully observe infants for increased sleepiness (more than usual), breathing difficulties, or limpness. Seek immediate medical care if you notice these signs. Living in a household where there are small children or someone who has abused street or prescription drugs. Taking prescription or over-the-counter medicines, vitamins, or herbal supplements. Taking oxymorphone with certain other medicines can cause serious side effects that could lead to death.

The severe or irreversible adverse effects of Oxymorphone, which give rise to further complications include Allergic reactions, Seizures, Muscle twitching, Dizziness.The signs and symptoms that are produced after the acute overdosage of Oxymorphone include Respiratory depression, Respiratory depression, Mydriasis, Cardiac arrest, Anorexia, Perspiration, Lacrimation, Insomnia.The symptomatic adverse reactions produced by Oxymorphone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Constipation, Dry mouth, Itching, Nausea and vomiting, Light headedness.

Get emergency help or call 911 right away if you take too much oxymorphone (overdose). When you first start taking oxymorphone, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Ask your healthcare provider about medicines like naloxone or nalmefene that can be used in an emergency to reverse an opioid overdose. Taking oxymorphone with other opioid medicines , benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death. Never give anyone else your oxymorphone . They could die from taking it. Selling or giving away oxymorphone is against the law. Store oxymorphone securely , out of sight and reach of children, and in a location not accessible by others, including visitors to the home.

Get emergency help or call 911 right away if you take too much oxymorphone (overdose). When you first start taking oxymorphone, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Ask your healthcare provider about medicines like naloxone or nalmefene that can be used in an emergency to reverse an opioid overdose. Taking oxymorphone with other opioid medicines , benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death. Never give anyone else your oxymorphone . They could die from taking it. Selling or giving away oxymorphone is against the law. Store oxymorphone securely , out of sight and reach of children, and in a location not accessible by others, including visitors to the home.

0.5 mg (0.5 (0.5)) As recommended. IV — 1 to 1.5 mg (1.2 (1.25)) As recommended. IM — Repeated every 4-6 hrs.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Oxymorphone can interact dangerously with many medications, potentially causing serious side effects or death. Always inform your doctor of all medications you take, including: Other opioids, pain medicines, or prescription cough medicines Sedatives, such as Xanax, Valium, Ativan, Klonopin, or Restoril Sleeping pills, muscle relaxants, or tranquilizers Mental health medications for depression, anxiety, or other conditions Neurological medications for Parkinson's disease, migraines, or seizures Antibiotics, antifungals, or HIV/hepatitis C treatments Heart or blood pressure medications Cold, allergy, or asthma medications Nausea, motion sickness, or bladder medications Some medications affect how oxymorphone is processed in the body, potentially raising levels to dangerous concentrations. This list is not complete; always check with your doctor or pharmacist before starting or stopping any medication, including over-the-counter products, vitamins, and herbal supplements.

No storage information is recorded for this medicine yet.