Pamidronate (Disodium Pentahydrate)

Pamidronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures. Pamidronate is used to treat Paget's disease of bone. Pamidronate is also used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy ). Pamidronate is also used to treat bone damage caused by certain types of cancer such as breast cancer or bone marrow cancer. Pamidronate does not treat the cancer itself. Pamidronate may also be used for purposes not listed in this medication guide.

Pamidronate is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures. Pamidronate is used to treat Paget's disease of bone. Pamidronate is also used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy ). Pamidronate is also used to treat bone damage caused by certain types of cancer such as breast cancer or bone marrow cancer. Pamidronate does not treat the cancer itself. Pamidronate may also be used for purposes not listed in this medication guide.

You should not use this medicine if you are allergic to mannitol, or to any bisphosphonate ( alendronate , etidronate, ibandronate , pamidronate, risedronate , tiludronate , or zoledronic acid ). To make sure pamidronate is safe for you, tell your doctor if you have ever had: an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); kidney disease; liver disease ; or a dental problem (you may need a dental exam before you receive pamidronate). In rare cases, this medicine may cause bone loss (osteonecrosis) in the jaw. Symptoms include jaw pain or numbness, red or swollen gums, loose teeth, or slow healing after dental work. The longer you use pamidronate, the more likely you are to develop this condition. Osteonecrosis of the jaw may be more likely if you have cancer or received chemotherapy, radiation, or steroids. Other risk factors include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. Pamidronate may harm an unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine. Tell your doctor if you become pregnant. You may also need to use birth control for several weeks after your last dose of pamidronate. This medicine can have long-lasting effects on your body. It is not known whether pamidronate passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using pamidronate. Pamidronate is not approved for use by anyone younger than 18 years old.

Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Pamidronate may cause serious side effects. Call your doctor at once if you have: high fever; new or unusual pain in your thigh or hip; a seizure; kidney problems --little or no urination, swelling in your feet or ankles, feeling tired or short of breath; low potassium --leg cramps, constipation , irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low calcium levels --muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Common side effects of pamidronate may include: fever, headache; bone pain; increased blood pressure; nausea, vomiting; low calcium or phosphate levels; or pain, redness, swelling or a hard lump under your skin around the IV needle. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Pamidronate may harm an unborn baby. Avoid getting pregnant while using pamidronate and tell your doctor if you become pregnant. Call your doctor if you have muscle spasms, numbness or tingling (in hands and feet or around the mouth), new or unusual hip pain, little or no urination, or swelling in your lower legs.

Pamidronate may harm an unborn baby. Avoid getting pregnant while using pamidronate and tell your doctor if you become pregnant. Call your doctor if you have muscle spasms, numbness or tingling (in hands and feet or around the mouth), new or unusual hip pain, little or no urination, or swelling in your lower legs.

200 mg (200 (200)) 24 hourly PO — 30 to 90 mg (60 (60)) As recommended. IV — Once or As Required

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Pamidronate can harm your kidneys. This effect is increased when you also use certain other medicines, including: antivirals, chemotherapy, injected antibiotics, medicine for bowel disorders, medicine to prevent organ transplant rejection, injectable osteoporosis medication, and some pain or arthritis medicines (including aspirin, Tylenol, Advil, and Aleve). Other drugs may interact with pamidronate, including prescription and over-the-counter medicines, vitamins, and herbal products . Tell your doctor about all your current medicines and any medicine you start or stop using.

Inj (reconstituted soln) Store in refrigerator.