Medicines/Generics/Pancuronium (Br)

Pancuronium (Br)

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

It is used to calm muscles during surgery . It is used to calm muscles while on a breathing machine.

Indications

It is used to calm muscles during surgery . It is used to calm muscles while on a breathing machine.

Contraindications

Pancuronium (Br) is contraindicated in conditions like Anuria, Neuromuscular disease, Documented hypersensitivity to any component of the product.

Side Effects

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash ; hives; itching ; red, swollen, blistered, or peeling skin with or without fever ; wheezing ; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Signs of high or low blood pressure like very bad headache or dizziness, passing out, or change in eyesight. Flushing. Redness. A fast heartbeat .

Warnings

Exercise caution in pre-existing pulmonary, liver or kidney diseases. Avoid over dosage of pancuronium bromide.

High Risk Groups

Drug should not be given to patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

0.01 to 0.02 mg/ kg (0.015 (0.015)) As recommended. IV — Incremental Dose. Overdosage should be avoided in obese patient. 0.02 to 0.06 mg/ kg (0.04 (0.04)) As recommended. IV — Initial Dose

Child Dosage

0.06 ug/kg (0.06 (0.06)) As recommended. Intra Venous — Initially for Once 10 to 20 ug/kg (15 (15)) As recommended. Intra Venous — Maintenance every 30 to 60 min, As Required

Neonatal Dosage

0.06 ug/kg (0.06 (0.06)) As recommended. Intra Venous — Initially for Once 10 to 20 ug/kg (15 (15)) As recommended. Intra Venous — Maintenance every 30 to 60 min, As Required

Drug Interactions

Pancuronium (Br) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlbuterolsalbutamol enhace neuromuscular blockade produced by neuromuscular blockers e.g pancuronium and vecuroniumAmikacin (Sulphate)Amikacin possess the neuromuscular blocking activity, which is additive with pancuronium result in severe and prolonged respiratory depression.MajorClosely monitor the vital signs. Adjust dosage regimen accordingly. Ventilatory support should be readily available in case of respiratory arrest.AzathioprineAzathioprine decreases or reverse the effects of pancuronium by inhibiting phosphodiestrase in motor nerve terminals.MinorPatient should monitored for neuromuscular blockade and dose adjustment is necessary.BambuterolBendrofluazideButorphanol (Tartrate)CarbamazepineCarbamazepine reduces the duration effect of pancuronium.ModerateDuring coadministration close observation for decreasing effect of pancuronium is recommended.ClindamycinDesfluraneDigoxinPancuronium may enhance the arrhythmogenic effect of Digoxin. ModerateMonitor for the development of cardiac arrhythmias when Pancuronium is administered to patients who are receiving Digoxin.EnfluraneEnflurane potentiate the effects of pancuronium.ModerateDose of pancuronium should be reduce if necessary.Ethacrynic AcidEtherFrusemide or FurosemideFurosemide may diminish the neuromuscular-blocking effect of Pancuronium. Furosemide may enhance the neuromuscular-blocking effect of Pancuronium. ModerateBe aware that the therapeutic effects of Pancuronium may be altered by coadministration of Furosemide. Low doses of the Furosemide appear to enhance blockade, whereas higher doses may diminish blockade.GentamicinGentamicin by interfering with Calcium influx decrease sensitivity of acetylcholine at postsynaptic membrane thus inhibit release of acetylcholine at neuromuscular junction resulting in severe respiratory depression and paralysis.Death may also reported due to additive effect of both drugs.MajorGentamicin is avoided when pancuronium is given during or immediately after surgery.Adjust dose.HalothaneHalothane potentiate the effect of pancuronium.ModerateDose of pancuronium should be reduced if necessary. Inhalational anesthetics should be administered only by specially trained personnels.HydroflumethiazideIsofluraneKetamine (HCl)LithiumMivacurium (Cl)NeomycinNitrous OxideStreptomycinStreptomycin may increase the actions and side effects of Pancuronium (Br).TerbutalineTetracycline (HCl)TheophyllineTriamcinolone These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Storage

Inj Store in refrigerator. Do not Freeze.