Papaverine (HCl)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Papaverine (HCl) is alkaloid devoid of narcotic properties and was first described and extracted from opium in 1848 and later synthesized in 1990. Papaverine (HCl) is a hydrochloride salt of opium alkaloid that may be obtained from opium after separation of morphine or prepared synthetically. Chemically Papaverine (HCl) is 6, 7-dimethoxy-1-veratrylisoquinoline hydrochloride. Papaverine (HCl) is a smooth muscle relaxant, dilates the arteries and increase the blood flow to the obstructed region, especially in the treatment of cerebral and the peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. Papaverine (HCl) is administered orally, intravenously and intramuscularly.
Indications
Papaverine (HCl) is primarily indicated in conditions like Bronchospasm, Cerebral ischemia, Cerebrovascular disease, Myocardial ischemia, Pulmonary embolism, Smooth muscle spasm.
Contraindications
Papaverine (HCl) is contraindicated in conditions like Glaucoma, Myocardial infarction, Cardiac failure, Cardiac stroke, Heart block, Bradycardia, Liver diseases.
Side Effects
The following side effects have been reported: general discomfort, nausea, abdominal discomfort, anorexia, constipation or diarrhea, skin rash, malaise, vertigo, headache, intensive flushing of the face, perspiration, increase in the depth of respiration, increase in heart rate, a slight rise in blood pressure, and excessive sedation.
Hepatitis, probably related to an immune mechanism, has been reported infrequently. Rarely, this has progressed to cirrhosis.
To report SUSPECTED ADVERSE REACTIONS, contact BPI Labs, LLC at (727) 471-0850 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch
Warnings
Papaverine should be used wit caution in patients with glaucoma.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Liver Malfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
30 to 120 mg (75 (75)) As recommended. IV,IM,Intra Arterial — 1-2 min. every 3 hrs.
75 to 300 mg (190 (187.5)) 8 hourly PO —
Child Dosage
Safety not establushed ( ) —
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Papaverine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementLevodopaLevodopaNicotine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Storage
Tab, Caps Store Below 40°C. Protect from Sunlight and Moisture.
Available Brands in Pakistan
No active brands are currently recorded for this generic.
1 record is present but flagged "Unverified / Legacy" and excluded.