Pegfilgrastim

Pegfilgrastim ( Neulasta brand and all biosimilars ) is used to reduce the risk of infection (febrile neutropenia) in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a high risk of febrile neutropenia. The Neulasta and Udenyca brands of pegfilgrastim are also FDA-approved to increase survival in patients acutely exposed to myelosuppressive doses of radiation (Hematopoietic Subsyndrome of Acute Radiation Syndrome). Pegfilgrastim is not approved for use in the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation.

Pegfilgrastim ( Neulasta brand and all biosimilars ) is used to reduce the risk of infection (febrile neutropenia) in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a high risk of febrile neutropenia. The Neulasta and Udenyca brands of pegfilgrastim are also FDA-approved to increase survival in patients acutely exposed to myelosuppressive doses of radiation (Hematopoietic Subsyndrome of Acute Radiation Syndrome). Pegfilgrastim is not approved for use in the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation.

Pegfilgrastim is contraindicated in conditions like Hypersensitivity to the drug.

Pegfilgrastim produces potentially life-threatening effects which include Allergic reactions, Respiratory distress syndrome. which are responsible for the discontinuation of Pegfilgrastim therapy.The symptomatic adverse reactions produced by Pegfilgrastim are more or less tolerable and if they become severe, they can be treated symptomatically, these include Myalgia, Arthralgia.

Pegfilgrastim may cause the following serious side effects: Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or your left shoulder. Call your healthcare provider or get emergency help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing. Pegfilgrastim can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, a fast heart rate, and sweating. If you have any of these symptoms, stop using pegfilgrastim and call your healthcare provider or get emergency medical help right away. You may have a serious sickle cell crisis, which could lead to death, if you have a sickle cell disorder and receive pegfilgrastim. Call your healthcare provider right away if you have symptoms of a sickle cell crisis, such as pain or difficulty breathing. Pegfilgrastim can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms: swelling of your face or ankles blood in your urine or dark colored urine urinating less frequently than usual. Your healthcare provider will check your blood during treatment with pegfilgrastim. Your healthcare provider will check your blood during treatment with pegfilgrastim. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with pegfilgrastim. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot. Pegfilgrastim can cause fluid to leak from blood vessels into your body’s tissues. This condition is called “Capillary Leak Syndrome” (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms: swelling or puffiness, and are urinating less than usual trouble breathing swelling of your stomach area (abdomen) and feeling of fullness dizziness or feeling faint a general feeling of tiredness. If you have breast cancer or lung cancer, when pegfilgrastim is used with chemotherapy and radiation therapy, or with radiation therapy alone, you may have an increased risk of developing a precancerous blood condition called myelodysplastic syndrome (MDS) or a blood cancer called acute myeloid leukemia (AML). Symptoms of MDS and AML may include tiredness, fever, and easy bruising or bleeding. Call your healthcare provider if you develop these symptoms during treatment with pegfilgrastim. Inflammation of the aorta (the large blood vessel that transports blood from the heart to the body) has been reported in patients who received pegfilgrastim. Symptoms may include fever, abdominal pain, feeling tired, and back pain. Call your healthcare provider if you experience these symptoms. This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Pegfilgrastim may cause the following serious side effects: Your spleen may become enlarged and can rupture. A ruptured spleen can cause death. Call your healthcare provider right away if you have pain in the left upper stomach area or your left shoulder. Call your healthcare provider or get emergency help right away if you have shortness of breath with or without a fever, trouble breathing, or a fast rate of breathing. Pegfilgrastim can cause serious allergic reactions. These reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness, swelling around your mouth or eyes, a fast heart rate, and sweating. If you have any of these symptoms, stop using pegfilgrastim and call your healthcare provider or get emergency medical help right away. You may have a serious sickle cell crisis, which could lead to death, if you have a sickle cell disorder and receive pegfilgrastim. Call your healthcare provider right away if you have symptoms of a sickle cell crisis, such as pain or difficulty breathing. Pegfilgrastim can cause kidney injury. Call your healthcare provider right away if you develop any of the following symptoms: swelling of your face or ankles blood in your urine or dark colored urine urinating less frequently than usual. Your healthcare provider will check your blood during treatment with pegfilgrastim. Your healthcare provider will check your blood during treatment with pegfilgrastim. Tell your healthcare provider if you have unusual bleeding or bruising during treatment with pegfilgrastim. This could be a sign of decreased platelet counts, which may reduce the ability of your blood to clot. Pegfilgrastim can cause fluid to leak from blood vessels into your body’s tissues. This condition is called “Capillary Leak Syndrome” (CLS). CLS can quickly cause you to have symptoms that may become life-threatening. Get emergency medical help right away if you develop any of the following symptoms: swelling or puffiness, and are urinating less than usual trouble breathing swelling of your stomach area (abdomen) and feeling of fullness dizziness or feeling faint a general feeling of tiredness. If you have breast cancer or lung cancer, when pegfilgrastim is used with chemotherapy and radiation therapy, or with radiation therapy alone, you may have an increased risk of developing a precancerous blood condition called myelodysplastic syndrome (MDS) or a blood cancer called acute myeloid leukemia (AML). Symptoms of MDS and AML may include tiredness, fever, and easy bruising or bleeding. Call your healthcare provider if you develop these symptoms during treatment with pegfilgrastim. Inflammation of the aorta (the large blood vessel that transports blood from the heart to the body) has been reported in patients who received pegfilgrastim. Symptoms may include fever, abdominal pain, feeling tired, and back pain. Call your healthcare provider if you experience these symptoms. This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

6 to 6 mg (6 (6)) As recommended. Sc — 6 mg administered subcutaneously once per chemotherapy cycle. Do not administer between 14 days before and 24 hours after administration of cytotoxic chemotherapy.

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Injection Do not Freeze. Protect from Sunlight and Heat.