Pemoline
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Pemoline belongs to the group of medicines called central nervous system (CNS) stimulants. It is used to treat children with attention-deficit hyperactivity disorder (ADHD).
Pemoline increases attention and decreases restlessness in children who are overactive, cannot concentrate for very long or are easily distracted, and are emotionally unstable. This medicine is used as part of a total treatment program that also includes social, educational, and psychological treatment.
Rarely, pemoline has caused serious liver problems. You and your doctor should talk about the good this medicine will do as well as the risks of using it. In addition, you will be asked to sign an informed consent form stating that you understand and agree to accept the risk of liver problems.
This medicine is available only with your doctor's prescription.
Indications
Pemoline belongs to the group of medicines called central nervous system (CNS) stimulants. It is used to treat children with attention-deficit hyperactivity disorder (ADHD).
Pemoline increases attention and decreases restlessness in children who are overactive, cannot concentrate for very long or are easily distracted, and are emotionally unstable. This medicine is used as part of a total treatment program that also includes social, educational, and psychological treatment.
Rarely, pemoline has caused serious liver problems. You and your doctor should talk about the good this medicine will do as well as the risks of using it. In addition, you will be asked to sign an informed consent form stating that you understand and agree to accept the risk of liver problems.
This medicine is available only with your doctor's prescription.
Contraindications
Pemoline is contraindicated in conditions like Liver diseases.
Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests.
Pemoline may cause some serious side effects, including liver problems. Also, medicines like pemoline, when used for a long time, have been reported to slow the growth rate of children. Some doctors recommend medicine-free periods during treatment with pemoline. Pemoline may also cause unwanted effects on behavior in children with severe mental illness.
Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Dark urine yellow eyes or skin
Check with your doctor as soon as possible if any of the following side effects occur:
Rare
Convulsions (seizures) hallucinations (seeing, hearing, or feeling things that are not there) nausea and vomiting shortness of breath, troubled breathing, wheezing, or tightness in chest skin rash sores, ulcers, or white spots on lips or in mouth swollen or painful glands uncontrolled movements of eyes, tongue, lips, face, arms, or legs unusual bleeding or bruising unusual tiredness vocal sounds you cannot control
Symptoms of overdose
Agitation confusion convulsions (seizures)—may be followed by coma false sense of well-being fast heartbeat hallucinations (seeing, hearing, or feeling things that are not there) headache (severe) high blood pressure high fever large pupils muscle trembling or twitching restlessness sweating vomiting
This medicine may also cause the following side effects that your doctor will watch for:
Rare
Liver problems slow growth in children
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Loss of appetite trouble in sleeping weight loss
Less common
Dizziness drowsiness headache increased irritability mental depression stomachache
After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:
Abdominal pain convulsions (seizures) headache mental depression nausea unusual behavior unusual tiredness or weakness vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Warnings
Pemoline should be used only after other treatments have failed. If this drug fails to work within a reasonable amount of time (within 3 weeks after ideal dosage has been determined) its use should be stopped. This medication has rarely caused severe (sometimes fatal) liver problems. Pemoline should be used only after other treatments have failed. If this drug fails to work within a reasonable amount of time (within 3 weeks after ideal dosage has been determined) its use should be stopped. This medication has rarely caused severe (sometimes fatal) liver problems.
High Risk Groups
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages, he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
56.25 to 75 mg/day (66 (65.625)) As recommended. PO — The recommended starting dose is 37.5 mg/day. The maximum recommended daily dose of pemoline is 112.5 mg.
Child Dosage
75 to 56.25 mg (66 (65.625)) 24 hourly PO — The max. recommended daily dose is 112.5 mg.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Iobenguane I 131
Storage
No storage information is recorded for this medicine yet.
Available Brands in Pakistan
No brands are recorded for this generic.
