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Medicines/Generics/Pentazocine

Pentazocine

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview
Pentazocine injection is used to relieve moderate to severe pain. It may also be used before surgery or with a general anesthetic (medicine that puts you to sleep). Pentazocine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. When a narcotic medicine is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. This medicine is available only with your doctor's prescription.
Indications
Pentazocine injection is used to relieve moderate to severe pain. It may also be used before surgery or with a general anesthetic (medicine that puts you to sleep). Pentazocine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. When a narcotic medicine is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. This medicine is available only with your doctor's prescription.
Contraindications
Pentazocine is contraindicated in conditions like Hypertension,Respiratory depression,Hypersensitivity,Raised intracranial pressure,Opioid dependence,CNS depression,Porphyria.
Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: Rare Black, tarry stools blistering, peeling, or loosening of the skin chest pain chills cough diarrhea fast, pounding, or irregular heartbeat or pulse fever itching joint or muscle pain painful or difficult urination red, irritated eyes red skin lesions, often with a purple center shakiness in the legs, arms, hands, or feet sore throat sores, ulcers, or white spots on the lips or in the mouth swelling or puffiness of the face swollen glands trembling or shaking of the hands or feet trouble breathing unusual bleeding or bruising unusual tiredness or weakness Incidence not known Blistering, crusting, irritation, itching, or reddening of the skin blue-green to black skin discoloration bluish lips or skin blurred vision burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings cold, clammy skin confusion cough cracked, dry, or scaly skin decrease in the frequency of urination decrease in urine volume depression difficult or troubled breathing difficulty in passing urine (dribbling) dizziness fainting fast or slow heartbeat fast, weak pulse flushed skin hardening or thickening of the skin headache increased sweating irregular, fast, slow, or shallow breathing lightheadedness nervousness pain, redness, or sloughing of the skin at the injection site pale or blue lips, fingernails, or skin pounding in the ears rapid breathing small lumps under the skin at the injection site stinging at the injection site sweating swelling of the lower legs or arms tightness in the chest very slow breathing weight gain Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common False or unusual sense of well-being nausea vomiting Rare Change in taste confusion about identity, place, and time constricted, pinpoint, or small pupils (black part of the eye) double vision seeing double seeing, hearing, or feeling things that are not there stomach cramps trouble sleeping uncontrolled eye movements Incidence not known Continuing ringing or buzzing or other unexplained noise in the ears difficulty having a bowel movement (stool) difficulty in focusing the eyes disturbed dreams drowsiness dry mouth excitement hearing loss irritability relaxed and calm sleepiness trouble sleeping weakness Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Warnings
Administer with caution and in low doses in patients with respiratory depression, liver disease, bronchial asthma. Pentazocine Lactate should generally be avoided after myocardial infarction and in patients with renal failure. Patients should observe caution while driving or performing other tasks requiring alertness because it may produce drowsiness.
High Risk Groups
Drug should not be given to Paediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
25 to 100 mg (62 (62.5)) 8 hourly PO — Frequency may increased to 4 times, if needed. 50 to 100 mg (75 (75)) 4 hourly IV,IM,SC — Not to exceed 600mg/day. Frequency may be increased upto 8 times if needed.
Child Dosage
No child dosage information is recorded for this medicine yet.
Neonatal Dosage
No neonatal dosage information is recorded for this medicine yet.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Nalmefene Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acepromazine Alfentanil Almotriptan Alprazolam Amifampridine Amineptine Amiodarone Amitriptyline Amitriptylinoxide Amobarbital Amoxapine Amphetamine Amprenavir Aprepitant Armodafinil Asenapine Atazanavir Baclofen Benperidol Benzhydrocodone Benzphetamine Boceprevir Bosentan Bromazepam Bromopride Brompheniramine Buprenorphine Bupropion Buspirone Butabarbital Butorphanol Calcium Oxybate Cannabidiol Cannabis Carbamazepine Carisoprodol Carphenazine Cetirizine Chloral Hydrate Chlordiazepoxide Chlorpheniramine Chlorpromazine Chlorzoxazone Ciprofloxacin Citalopram Clarithromycin Clobazam Clomipramine Clonazepam Clorazepate Clozapine Cobicistat Cocaine Codeine Conivaptan Crizotinib Cyclosporine Daridorexant Darunavir Delavirdine Desipramine Desmopressin Desvenlafaxine Dexamethasone Dexmedetomidine Dextroamphetamine Dextromethorphan Dezocine Diazepam Dibenzepin Dichloralphenazone Difenoxin Diltiazem Diphenhydramine Diphenoxylate Dolasetron Donepezil Doxepin Dronedarone Droperidol Duloxetine Efavirenz Eletriptan Enflurane Enzalutamide Erythromycin Escitalopram Esketamine Eslicarbazepine Acetate Estazolam Eszopiclone Ethchlorvynol Ethopropazine Ethylmorphine Etravirine Fenfluramine Fentanyl Flibanserin Fluconazole Fluoxetine Fluphenazine Flurazepam Fluspirilene Fluvoxamine Fosamprenavir Fosaprepitant Fosphenytoin Fospropofol Frovatriptan Furazolidone Gabapentin Gabapentin Enacarbil Gepirone Granisetron Halazepam Haloperidol Halothane Hexobarbital Hydrocodone Hydromorphone Hydroxyamphetamine Hydroxytryptophan Hydroxyzine Idelalisib Imatinib Imipramine Indinavir Iproniazid Isocarboxazid Isoflurane Itraconazole Ivacaftor Ketamine Ketazolam Ketobemidone Ketoconazole Lacosamide Lasmiditan Lemborexant Levocetirizine Levomilnacipran Levorphanol Linezolid Lisdexamfetamine Lithium Lofepramine Lofexidine Lomitapide Lopinavir Lorazepam Lorcaserin Loxapine Lumacaftor Magnesium Oxybate Meclizine Melitracen Melperone Meperidine Mephobarbital Meprobamate Meptazinol Mesoridazine Metaxalone Methadone Methamphetamine Methdilazine Methocarbamol Methohexital Methotrimeprazine Methylene Blue Metoclopramide Mibefradil Midazolam Mifepristone Milnacipran Mirtazapine Mitotane Moclobemide Modafinil Molindone Moricizine Morphine Nafcillin Nalbuphine Naratriptan Nefazodone Nelfinavir Nevirapine Nialamide Nicomorphine Nilotinib Nitrazepam Nitrous Oxide Nortriptyline Olanzapine Ondansetron Opipramol Opium Opium Alkaloids Orphenadrine Oxazepam Oxcarbazepine Oxycodone Oxymorphone Palbociclib Palonosetron Papaveretum Paregoric Paroxetine Pentobarbital Perampanel Perazine Periciazine Perphenazine Phenelzine Phenobarbital Phenytoin Pimozide Piperacetazine Pipotiazine Piritramide Posaconazole Potassium Oxybate Prazepam Prednisone Pregabalin Primidone Procarbazine Prochlorperazine Promazine Promethazine Propofol Protriptyline Quazepam Quetiapine Ramelteon Ranitidine Ranolazine Rasagiline Remifentanil Remimazolam Remoxipride Rifabutin Rifampin Rifapentine Ritonavir Rizatriptan Ropeginterferon Alfa-2b-njft Saquinavir Scopolamine Secobarbital Selegiline Sertindole Sertraline Sibutramine Sodium Oxybate St John's Wort Sufentanil Sulpiride Sumatriptan Suvorexant Tapentadol Telaprevir Telithromycin Temazepam Thiethylperazine Thiopental Thiopropazate Thioridazine Tianeptine Tilidine Tizanidine Tolonium Chloride Topiramate Tramadol Tranylcypromine Trazodone Triazolam Trifluoperazine Trifluperidol Triflupromazine Trimeprazine Trimipramine Tryptophan Venlafaxine Verapamil Vilazodone Voriconazole Vortioxetine Zaleplon Ziprasidone Zolpidem Zopiclone Zotepine Zuranolone
Storage
Inj, Tab Store Below 40°C. Do not Freeze. Protect from Sunlight.