Pergolide

It is used to treat Parkinson's disease .

It is used to treat Parkinson's disease .

Pergolide is contraindicated in conditions like Valvular heart disease, Pericarditis, Fibrositis, Hypersensitivity to any component of product.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash ; hives; itching ; red, swollen, blistered, or peeling skin with or without fever ; wheezing ; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain. Chest pain. Cough that does not go away. Very bad dizziness or passing out. Trouble controlling body movements that is new or worse. Hallucinations (seeing or hearing things that are not there). Feeling confused. Change in how you act. Strong urges that are hard to control (such as eating, gambling, sex, or spending money). Change in eyesight. Rarely, heart valve problems have happened with pergolide. Call your doctor right away if you have a fast or abnormal heartbeat, shortness of breath, swelling in the arms or legs, or a big weight gain. A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache , confusion, change in thinking, fast heartbeat , heartbeat that does not feel normal, or are sweating a lot.

Pergolide should be used with caution in patients with pre-existing heart disease or a history of heart arrhythmias (abnormal rhythms), hallucinations, mental confusion, difficulty in walking, allergies, kidney disease or low blood pressure. Caution should be exercised when administering pergolide mesylate to patients prone to cardiac dysrhythmias. In a study comparing pergolide mesylate and placebo, patients taking pergolide mesylate were found to have significantly more episodes premature contractions (PACs) and sinus tachycardia. Patients and their families should be informed of the common adverse consequences of the use of pergolide mesylate and the risk of hypotension. Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy. Patients should be advised to notify their physician if they are breast feeding an infant. Liver disease may alter the response to drugs in several ways. Prescribing should be kept to a minimum in all patients with severe liver disease, especially if jaundice, ascites, or evidence of encephalopathy present. Consider dose reduction in renal failure to avoid possibility of toxicity, increased sensitivity, and side effects. Get up slowly, to avoid dizziness and lightheadedness when rising from a seated or lying position. It should be used with caution when performing tasks requiring mental alertness such as driving or using machinery. Limit alcohol use because it may intensify the drowsiness and dizziness effects of this drug. It should be used with caution during pregnancy.

Drug should not be given to Pediatrics, Pregnant Mothers, patients suffering from Kidney dysfunction, patients suffering from Liver Malfunction, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

150 ug (150 (150)) As recommended. PO — On day 1 at night. 50 ug (50 (50)) 12 hourly PO — On days 2-4, then 100-200 ug daily every 3-4 days in 3 div.doses.

( ) —

( ) — Not recommended in this age group

Pergolide is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementDomperidoneFluoxetine (HCl)Theoretical potential for FLUOXETINE HYDROCHLORIDE increasing the EXTRAPYRAMIDAL side effects of PERGOLIDE MESILATE. Usually no risk. Usually no action necessary.LisinoprilInfrequent reports of PERGOLIDE MESILATE increasing the HYPOTENSIVE effect of LISINOPRIL. Usually no risk. Usually no action necessary.MemantineLikely interaction of MEMANTINE increasing the DOPAMINERGIC effect of PERGOLIDE MESILATE. May need to avoid combinationMajorMetoclopramide (HCl)Octreotide (Acetate)PimozideLikely interaction of PERGOLIDE MESILATE increasing the EXTRAPYRAMIDAL side effects of PIMOZIDE. Selegiline (HCl)VORICONAZOLEVoriconazole may increase the serum concentration of pergolide likely by decreasing its metabolism. Concomitant therapy is contraindicated.Warfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

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