Perindopril
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Perindopril is an ACE inhibitors . ACE stands for angiotensin converting enzyme.
Perindopril is used to treat high blood pressure (hypertension) and to prevent heart attack in people with coronary artery disease .
Perindopril may also be used for purposes not listed in this medication guide.
Indications
Perindopril is an ACE inhibitors . ACE stands for angiotensin converting enzyme.
Perindopril is used to treat high blood pressure (hypertension) and to prevent heart attack in people with coronary artery disease .
Perindopril may also be used for purposes not listed in this medication guide.
Contraindications
You should not use this medicine if you are allergic to perindopril or if:
you have hereditary angioedema ; you recently took a heart medicine called sacubitril; or you are allergic to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril, lisinopril , moexipril, quinapril, ramipril, or trandolapril .
Do not take perindopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use perindopril together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking perindopril with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
kidney disease (or if you are on dialysis); liver disease ; heart disease or congestive heart failure ; diabetes; or a connective tissue disease such as Marfan syndrome , Sjogren's syndrome , lupus, scleroderma , or rheumatoid arthritis .
Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Perindopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. You may be more likely to have an allergic reaction if you are African-American.
Perindopril may cause serious side effects. Call your doctor at once if you have:
a light-headed feeling, like you might pass out; fever, chills, body aches, flu symptoms, sores in your mouth and throat; little or no urination; swelling, rapid weight gain; high potassium --nausea, slow or unusual heart rate, weakness, loss of movement; pale skin, easy bruising or bleeding; or jaundice (yellowing of the skin or eyes).
Common side effects of perindopril may include:
dizziness; back pain; or cough.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
Do not use if you are pregnant. If you become pregnant, stop taking perindopril and tell your doctor right away.
You should not use perindopril if you have ever had angioedema. Do not take perindopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use perindopril together with any medication that contains aliskiren (a blood pressure medicine).
High Risk Groups
Do not use if you are pregnant. If you become pregnant, stop taking perindopril and tell your doctor right away.
You should not use perindopril if you have ever had angioedema. Do not take perindopril within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).
If you have diabetes, do not use perindopril together with any medication that contains aliskiren (a blood pressure medicine).
Adult Dosage
2 mg (2 (2)) As recommended. PO — For Congestive heart failure: Dose may be increased to 4 mg once blood pressure acceptability has been demonstrated.
4 mg (4 (4)) As recommended. PO — For Hypertension: once daily.
4 to 8 mg (6 (6)) As recommended. PO — Increased to max. after 1 month therapy
Scraped Dose — Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take each dose with a full glass of water. Drink plenty of liquids while you are taking perindopril.
You may take perindopril with or without food.
Your blood pressure will need to be checked often. Your kidney or liver function may also need to be checked.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking perindopril. This can lead to very low blood pressure , electrolyte disorders, or kidney failure .
If you need surgery, tell the surgeon ahead of time that you are using perindopril.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat.
Child Dosage
( ) — Not recommended in this age group
Neonatal Dosage
( ) — Not recommended in this age group
Drug Interactions
Tell your doctor about all your other medicines, especially:
lithium; a diuretic or "water pill"; gold injections to treat arthritis; or NSAIDs (nonsteroidal anti-inflammatory drugs) --aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin , meloxicam, and others.
This list is not complete. Other drugs may affect perindopril, including prescription and over-the-counter medicines, vitamins, and herbal products . Not all possible drug interactions are listed here.
Storage
Tab Store Below 25°C.