Pethidine (HCl)

Pethidine (HCl) is a synthetic narcotic analgesic. The actions and adverse effects similar to that of morphine. Pethidine (HCl) is used to relieve severe pain. It is also an antispasmodic. It can produce coma with danger of death on overdosage. Naloxone is a specific antagonist. Tolerance or physical dependence may occur after a long-term use.

Pethidine (HCl) is primarily indicated in conditions like Acute pain, Headache, Labor, Moderate to severe pain, Obstetric analgesia, Obstetric pain, Pain, Parkinson's disease; drug-induced extrapyramidal symptoms, Post-operative shivering, Pre-anesthetic medication, Severe pain and tenderness in benign fibrocystic breast disease, Surgery, and can also be given in adjunctive therapy as an alternative drug of choice in All forms of epilepsy, Myoclonus.

Pethidine (HCl) is contraindicated in conditions like Asthma, Epilepsy, Pheochromocytoma, Respiratory depression, Status epilepticus, Tetanus, Liver diseases, Hypersensitivity, Raised intracranial pressure, Supraventricular tachycardia, Kidney disease.

The severe or irreversible adverse effects of Pethidine (HCl), which give rise to further complications include Convulsions, Hallucinations, Vertigo, Tachycardia, Hypotension, Skin rashes, Myoclonus, GI symptoms, Hypertension, Dizziness. Pethidine (HCl) produces potentially life-threatening effects which include Coma, Respiratory depression, Convulsions, Hypotension, Dependence. which are responsible for the discontinuation of Pethidine (HCl) therapy. The signs and symptoms that are produced after the acute overdosage of Pethidine (HCl) include Bradycardia, Hypotension, Disorientation, Seizures, Dry mouth, Respiratory depression, Hypothermia, Hallucinations, Delirium, Tremor, Mydriasis, CNS depression, Cyanosis. The symptomatic adverse reactions produced by Pethidine (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Weakness, Drowsiness, Nausea, Vomiting, Constipation, Dry mouth, Urticaria, Pruritus, Erythema, Malaise, Hypersensitivity, Nausea and vomiting, Light headedness, Fibrosis, Twitching.

Pethidine should be used with caution in patients with supraventricular tachycardia, history of convulsive disorder or pulmonary depression. It should be used with caution during pregnancy. Do not drive as Pethidine may cause drowsiness. Pethidine should not be used for long term as its effectiveness may decrease. Use with caution in babies less than 1 month, in patients with breathing problems, convulsions or hypothyroidism.

Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

50 to 100 mg (75 (75)) 4 hourly IM,SC —

0.5 to 0.2 mg/kg (0.35 (0.35)) 4 hourly Intra Muscular — - 0.5 to 2 mg/kg (1.2 (1.25)) 4 hourly Oral —

1 to 2 (1.5 (1.5)) 4 hourly Intramuscular —

Pethidine (HCl) is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholBromazepamButorphanol (Tartrate)Chlorpromazine (HCl)Cimetidine (HCl)DisulfiramEtomidateFosphenytoinIotroxate (Meglumine)MethadoneNitrous OxidePerphenazinePhenobarbitonePhenytoin (Na)PrazepamPromethazine (HCl)RitonavirSelegiline (HCl)SibutramineTechnetium Tc-99m OxidronatePossible accumulation of technetium Tc 99m oxidronate at site[s] of injection of Pethidine (HCl).Thiopentone (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Inj Store Below 40°C. Protect from Sunlight.