Phenylbutazone

It is used to treat ankylosing spondylitis .

It is used to treat ankylosing spondylitis .

Phenylbutazone is contraindicated in conditions like Peptic ulcer, Blood dyscrasias, Congestive heart failure, Hepatitis.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing ; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop. Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain. Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight. Shortness of breath , a big weight gain, or swelling in the arms or legs. Chest pain or pressure. Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Change in eyesight. Ringing in ears. A burning, numbness, or tingling feeling that is not normal. Low mood ( depression ). Feeling confused. Hallucinations (seeing or hearing things that are not there). Very bad belly pain. Feeling very tired or weak. A very bad skin reaction ( Stevens-Johnson syndrome / toxic epidermal necrolysis ) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

Phenylbutazone should be used with caution in patients with incipient cardiac failure, blood dyscrasias, pancreatitis, kidney or liver diseases, gastrointestinal (GI) inflammation. Patients should observe caution while driving or performing other tasks requiring alertness, because it may cause drowsiness.

Drug should not be given to Pregnant Mothers, Geriatrics, and Neonates. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

100 mg (100 (100)) 8 hourly PO — Maintenance, As Required 200 mg (200 (200)) 8 hourly PO — Initially for 2 Days

( ) — Not recommended in this age group

( ) — Not recommended in this age group

Phenylbutazone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAlcoholAluminium Hydroxide and OxideAspirinCoadministration exacerbate the serious gastrointestinal toxicity. Aspirin at higher doses also decreases the plasma concentration of phenylbutazoneModerateCoadministration should be avoided due to increased risk of toxicity. Patient should take medication with food and should report the sign and symptoms of GI ulceration and bleeding to physician immediately.ChlorambucilChloroquineChlorpropamidePhenylbutazone inhibit the metabolism and renal clearence of chlorpropamide and displace it from plasma protein binding site thus potentiate the hypoglycaemic effect.ModerateMonitor blood sugar regularly. Closely monitor for increased hypoglycemic effect. Reduce the dose of chlorpropamide if necessary.CholestyramineClozapineBoth agents acts additively thus enhances the risk and severity of hematologic toxicityMajorThis combination should be avaoided due to increased risk of agranulocytosis and bone marrow suppression.Colestipol (HCl)EthinyloestradiolEtodolacFenbufenFenoprofenFloctafenineFlurbiprofenFosphenytoinGestodeneGlibornurideGliclazideGliquidoneGlymidineLiothyronine (Na)Magnesium Oxides and HydroxidesMeloxicamMethotrexateMethylphenidate (HCl)MetyrosineTheoretical potential for PHENYLBUTAZONE reducing the HYPOTENSIVE effect of METIROSINEModerateOxaprozinPerindoprilTheoretical potential for PHENYLBUTAZONE reducing the HYPOTENSIVE effect of Perindopril Erbumine. ModeratePhenobarbitonePhenytoin (Na)Phenytoin (Na)SulfapyridinePhenylbutazone has also been reported to potentiate the effects of sulfonamides.SulphamethizolePhenylbutazone may displace sulfonamides from plasma protein binding sites, increasing sulfonamide concentrations.TenoxicamThyroxine (Na)TolbutamideTolbutamideWarfarin (Na) These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

Tab Store Below 25°C. Protect from Moisture.