Physostigmine
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Physostigmine affects chemicals in the body that control the signals sent from the nervous system to the muscles to activate muscle movement.
Physostigmine is used to reverse the effects of certain drugs or substances that interfere with this nerve-muscle communication. Such substances include atropine , scopolamine , belladonna , antihistamines , some antidepressants , and other anticholinergic (AN tye KOE lin ER jik) drugs.
Physostigmine may also be used for purposes not listed in this medication guide.
Indications
Physostigmine affects chemicals in the body that control the signals sent from the nervous system to the muscles to activate muscle movement.
Physostigmine is used to reverse the effects of certain drugs or substances that interfere with this nerve-muscle communication. Such substances include atropine , scopolamine , belladonna , antihistamines , some antidepressants , and other anticholinergic (AN tye KOE lin ER jik) drugs.
Physostigmine may also be used for purposes not listed in this medication guide.
Contraindications
You should not be treated with physostigmine if you are allergic to it, or if you have:
asthma; diabetes; bladder obstruction or other urination problems; a blockage in your digestive tract (stomach or intestines); heart disease ; or gangrene (damaged skin and muscle tissue caused by infection or lack of blood supply).
If possible before you receive physostigmine, tell your doctor if:
you have a sulfite allergy; you have recently taken Ultracet ( acetaminophen with tramadol ); or you regularly take bupropion ( Wellbutrin , Zyban, Aplenzin , Forfivo, and others).
In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine.
Side Effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers right away if you have:
increased urination or bowel movements; stomach cramps; severe or worsening nausea or vomiting; increased sweating; blurred vision; or excessive saliva in your mouth.
Common side effects of physostigmine may include:
nausea, vomiting; increased salivation; or slow heartbeats.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received physostigmine.
High Risk Groups
In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received physostigmine.
Adult Dosage
0.25 to 0.5 % (0.38 (0.375)) As recommended. Ophthalmic — As Required
Child Dosage
Safety not established ( ) —
Neonatal Dosage
Safety not established ( ) —
Drug Interactions
Other drugs may interact with physostigmine, including prescription and over-the-counter medicines, vitamins, and herbal products . Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Storage
Inj Store Below 40°C. Do not Freeze. Protect from Sunlight.
Available Brands in Pakistan
No brands are recorded for this generic.