Medicines/Generics/Phytomenadione

Phytomenadione

Generic medicine reference

Not yet clinically reviewed

This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.

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Overview

Phytomenadione or vitamin K1, is a synthetic compound that is chemically indistinguishable from naturally occurring vitamin K1. Vitamin K is found in both plant and animal sources, and is also produced by intestinal bacteria; however, vitamin K from these different sources is not identical. Phytonadione is found in plants and is the only natural vitamin K available for therapeutic use. Menaquinones (vitamin K 2) are a series of compounds that can be synthesized by bacteria. Vitamin K is an essential cofactor in the hepatic synthesis of prothrombin and other blood clotting factors. vitamin K decreases the effects of oral anticoagulants, and is used to counteract excessive effects of these drugs.

Indications

Phytomenadione is primarily indicated in conditions like Hemorrhage, Hemorrhagic disease of newborn, Hypoprothrombinemia.

Contraindications

Phytomenadione is contraindicated in conditions like Hypersensitivity to any component of product.

Side Effects

The signs and symptoms that are produced after the acute overdosage of Phytomenadione include Hyperbilirubinemia, Jaundice, Hemolytic anemia. The symptomatic adverse reactions produced by Phytomenadione are more or less tolerable and if they become severe, they can be treated symptomatically, these include Sweating, Flushing, Cyanosis.

Warnings

Phytomenadione should be used as directed during pregnancy or lactation. It should be used with caution in patients with any pre-existing blood disorders or allergy.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

Adult Dosage

10 to 20 mg (15 (15)) As recommended. PO — As Required 20 to 2.5 mg (11 (11.25)) As recommended. IV,IM,SC — As Required

Child Dosage

0.3 mg/kg (0.3 (0.3)) As recommended. Intra Muscular — Single Dose 0.3 mg/kg (0.3 (0.3)) As recommended. Oral — Single Dose 0.3 mg/kg (0.3 (0.3)) As recommended. slow Intra venous — Single Dose

Neonatal Dosage

0.3 mg/kg (0.3 (0.3)) As recommended. Intra Muscular — Single Dose 0.3 mg/kg (0.3 (0.3)) As recommended. Oral — Single Dose 0.3 mg/kg (0.3 (0.3)) As recommended. slow Intra venous — Single Dose

Drug Interactions

No data regarding the interactions of Phytomenadione was found.

Storage

Inj Store Below 40°C. Do not Freeze. Protect from Sunlight. Tab Store in a well closed container, Below 40°C. Protect from Sunlight.