Pivmecillinam (HCl)
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Pivmecillinam (HCl) or amdinocillin pivoxil is an orally active prodrug of mecillinam, an extended-spectrum penicillin antibiotic. Pivmecillinam is the pivaloyloxymethyl ester of mecillinam. Pivmecillinam (HCl) is antibiotic and is used to treat a large variety of bacterial infections, such as respiratory tract infections, middle ear infections, skin infections and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular intervals of time throughout the day and night as prescribed. Pivmecillinam (HCl) is important to take the drug for the full time period as prescribed. Discontinuation of the drug may result in ineffective treatment.
Indications
Pivmecillinam (HCl) is primarily indicated in conditions like Acute uncomplicated cystitis, Chronic or recurrent bacteriuria, Salmonellosis, UTI.
Contraindications
Pivmecillinam (HCl)
Side Effects
The symptomatic adverse reactions produced by Pivmecillinam (HCl) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Diarrhea, Anaphylactoid reactions, Abdominal pain, Mouth ulcers, Nausea and vomiting, Thrombocytopenia, Eosinophilia, Granulocytopenia, Esophageal ulcerations, Esophagitis.
Warnings
During long term use, it is advisable to carry out routine liver and kidney function tests. Pivmecillinam (HCl) should be used with caution in patients with porphyria since Pivmecillinam has been associated with acute attacks of porphyria. As with other antibiotics which are excreted mainly by the kidneys, raised blood levels of Mecillinam may occur if repeated doses are given to patients with impaired renal function. Pivmecillinam (HCl) should be used with caution for long-term or frequently-repeated treatment, due to the possibility of carnitine depletion.
High Risk Groups
Drug should not be given to Pregnant Mothers.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Adult Dosage
2.857 mg/kg (2.9 (2.857)) 8 hourly PO — Maintenance, upto 8 doses
5.714 mg/kg (5.7 (5.714)) As recommended. PO — Loading
Child Dosage
5 to 10 mg/kg (7.5 (7.5)) 6 hourly Oral — -
Neonatal Dosage
5 to 10 mg/kg (7.5 (7.5)) 6 hourly Oral —
Drug Interactions
No data regarding the interactions of Pivmecillinam (HCl) was found.
Storage
Tab, Oral Susp Store in refrigerator. Protect from Sunlight.
Available Brands in Pakistan
No brands are recorded for this generic.