Plicamycin

Plicamycin belongs to the group of medicines known as antineoplastics. It may be used to treat certain types of cancer. It is also used to treat hypercalcemia or hypercalciuria (too much calcium in the blood or urine) that may occur with some types of cancer. Plicamycin may also be used for other conditions as determined by your doctor. Plicamycin is to be administered by or under the immediate care of your doctor. It was available only with a prescription. The manufacturer discontinued plicamycin in 2000 .

Plicamycin belongs to the group of medicines known as antineoplastics. It may be used to treat certain types of cancer. It is also used to treat hypercalcemia or hypercalciuria (too much calcium in the blood or urine) that may occur with some types of cancer. Plicamycin may also be used for other conditions as determined by your doctor. Plicamycin is to be administered by or under the immediate care of your doctor. It was available only with a prescription. The manufacturer discontinued plicamycin in 2000 .

Plicamycin is contraindicated in conditions like Thrombocytopenia, Pregnancy, Coagulation disorder.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Muscle and abdominal cramps Symptoms of overdose Bloody or black, tarry stools flushing or redness or swelling of face nosebleed skin rash or small red spots on skin sore throat and fever unusual bleeding or bruising vomiting of blood yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea irritation or soreness of mouth loss of appetite nausea or vomiting—may occur 1 to 2 hours after the injection is started and continue for 12 to 24 hours Less common Drowsiness fever headache mental depression pain, redness, soreness, or swelling at place of injection unusual tiredness or weakness After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects: Bloody or black, tarry stools nosebleed sore throat and fever unusual bleeding or bruising vomiting of blood Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

It should not be given with great caution in patient with impaired hepatic or renal function. Blood cell counts, bleeding time, prothrombin time, hepatic and renal function should be determined frequently during treatment and for several days after, and treatment stopped if there is any sudden change.

Drug should not be given to Pregnant Mothers. If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.

25 to 30 mcg/kg of body weight (28 (27.5)) As recommended. IV —

No child dosage information is recorded for this medicine yet.

No neonatal dosage information is recorded for this medicine yet.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Inf (reconstituted) Store at room temperature. Protect from Sunlight. Use within 4-6 hrs if kept at room temperature. Inj (reconstituted soln) Protect from Sunlight.