Pralidoxime
Generic medicine reference
Not yet clinically reviewed
This entry was migrated from the earlier Pharmapedia app bundle and has not been reviewed by a named clinician on this site. It is provided for educational reference only — verify dosage and safety information against current, authoritative sources and a qualified healthcare professional before any clinical use.
Overview
Pralidoxime is used as an antidote to treat poisoning caused by chemicals, pesticides (insect sprays), or drugs used to treat a muscle disorder.
This medication is not effective as an antidote for all types of pesticide poisonings.
Pralidoxime may also be used for purposes not listed in this medication guide.
Indications
Pralidoxime is used as an antidote to treat poisoning caused by chemicals, pesticides (insect sprays), or drugs used to treat a muscle disorder.
This medication is not effective as an antidote for all types of pesticide poisonings.
Pralidoxime may also be used for purposes not listed in this medication guide.
Contraindications
If possible during an emergency, tell your caregivers if you've ever had:
an allergy to any medication; liver or kidney disease; heart problems; or high blood pressure .
If possible during an emergency, tell your caregivers if you are pregnant or breastfeeding.
Side Effects
Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some of the side effects of pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.
Tell your caregivers right away if you have:
fast or pounding heartbeats; chest tightness, shortness of breath ; anxiety , dizziness, or nervousness; numbness or tingling; painful or difficult urination; little or no urination; vision problems; or muscular weakness.
Side effects may be more likely in older adults.
Common side effects of pralidoxime may include:
pain for up to an hour after injection into a muscle; trouble breathing; vision changes; nausea ; fast heartbeats, increased blood pressure; headache , dizziness, drowsiness ; or muscle weakness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Warnings
If you receive pralidoxime during an emergency, make sure any follow-up doctor knows you received pralidoxime.
High Risk Groups
If you receive pralidoxime during an emergency, make sure any follow-up doctor knows you received pralidoxime.
Adult Dosage
0.01 to 0.07 mg/kg (0.04 (0.04)) 0.5 hourly IM — -
0.01 to 0.07 mg/kg (0.04 (0.04)) 0.5 hourly IV — -
1.43 to 4.28 mg/kg.min (2.9 (2.855)) As recommended. IV Inf — For 15-30 Minutes
Child Dosage
20 to 60 mg/kg (40 (40)) As recommended. Slow IV — Single Dose, can be repeated As Required
Neonatal Dosage
20 to 60 mg/kg (40 (40)) As recommended. Slow IV — Single Dose, can be repeated As Required
Drug Interactions
Tell your doctor about all your other medicines, especially:
atropine ; morphine ; a barbiturate such as phenobarbital ; medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia ; or a bronchodilator -- aminophylline , theophylline .
This list is not complete. Other drugs may affect pralidoxime, including prescription and over-the-counter medicines, vitamins , and herbal products . Not all possible drug interactions are listed here.
Storage
IV Inj, IV Inf, IM Inj , SC Inj Store Below 25°C. Protect from Sunlight.
Available Brands in Pakistan
1 active brand listed alphabetically.
P-DOXIME
ActiveATCO LABORATORIES LIMITED
DML: P-DOXIME
Inj
1 additional record is present but flagged "Unverified / Legacy" and not listed.